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Title: Omics-Lethal Human Viruses, West Nile Experiment WCT001

Abstract

The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV-NY99 382) and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt) virus infection. Sample data was obtained from mouse cortex tissue for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Tissues from this experiment were matched to tissues from GSE77192 (WCB001), using 1/4 of the cortex and 1/2 of cerebellum from the same mice. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific West Nile virus infection.

Authors:
ORCiD logo ; ORCiD logo ; ORCiD logo
  1. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
  2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
Publication Date:
Other Number(s):
WCT001
NCBI BioProjec: PRJNA309682 (mRNA);NCBI BioProject: PRJNA309680 (miRNA);GEO series: GSE77193 (mRNA);GEO series: GSE77161 (miRNA);MassIVE: MSV000081048 (lipidome);MassIVE: MSV000080019 (metabolome);MassIVE: MSV000080361 (proteome)
DOE Contract Number:  
AC05-76RL01830
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
Collaborations:
Modeling Host Responses to Understand Severe Human Virus Infections Program Project
Subject:
59 BASIC BIOLOGICAL SCIENCES
Keywords:
Virology [edam.topic:0781]; Immune Response [GO:0006955]; Mus musculus [NCBITAXON:10090]; West Nile Virus [NCBITAXON:11082]; Time Sampled Measurement Datasets [IAO:0000584]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Gene expression profile data [edam.data:0928]; BioProject Accession Number [NCIT:C175890]; Omics [edam.topic:3391]; Multi-omics [edam.topic:4021]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Data Download [schema:DataDownload]
OSTI Identifier:
1661954
DOI:
https://doi.org/10.25584/LHVWCT001/1661954

Citation Formats

Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. Omics-Lethal Human Viruses, West Nile Experiment WCT001. United States: N. p., 2021. Web. doi:10.25584/LHVWCT001/1661954.
Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. Omics-Lethal Human Viruses, West Nile Experiment WCT001. United States. doi:https://doi.org/10.25584/LHVWCT001/1661954
Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021. "Omics-Lethal Human Viruses, West Nile Experiment WCT001". United States. doi:https://doi.org/10.25584/LHVWCT001/1661954. https://www.osti.gov/servlets/purl/1661954. Pub date:Mon Jan 18 00:00:00 EST 2021
@article{osti_1661954,
title = {Omics-Lethal Human Viruses, West Nile Experiment WCT001},
author = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},
abstractNote = {The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV-NY99 382) and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt) virus infection. Sample data was obtained from mouse cortex tissue for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Tissues from this experiment were matched to tissues from GSE77192 (WCB001), using 1/4 of the cortex and 1/2 of cerebellum from the same mice. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific West Nile virus infection.},
doi = {10.25584/LHVWCT001/1661954},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {1}
}

Works referenced in this record:

Hypergraph models of biological networks to identify genes critical to pathogenic viral response
journal, May 2021


    Works referencing / citing this record:

    PNNL DataHub Omics Lethal Human Viruses Project, Modeling Host Responses to West Nile Infection Post-Processed Data Package DOIs
    dataset, January 2021