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Title: Omics-Lethal Human Viruses, Interferon-Stimulated Response Experiment IFNaHUH001

Abstract

The purpose of this experiment was to evaluate the human host cellular response to treatment with and without interferon alpha/beta (IFNα/β) treatment. Sample time course data was obtained from human hepatoma carcinoma cells (HUH-7) expressing transcriptional activation protein VP30, stably transfected with the Ebola VP30 gene for enabling replication of VP30-deficient Ebola virus for transcriptome expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset download have a direct relationship to a primary sample submission corresponding to a specific interferon response to viral infection.

Authors:
ORCiD logo ; ORCiD logo ; ORCiD logo
  1. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
  2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
Publication Date:
Other Number(s):
IFNaHUH001
NCBI BioProject: PRJNA417084 (mRNA);GEO Series: GSE106522 (mRNA)
DOE Contract Number:  
AC05-76RL01830
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
Collaborations:
Modeling Host Responses to Understand Severe Human Virus Infections Program Project
Subject:
59 BASIC BIOLOGICAL SCIENCES
Keywords:
Virology [edam.topic:0781]; Immune Response [GO:0006955]; Human virus [NCIT:C14317]; Ebola virus [NCBITAXON:186536]; Human Interferon [NCIT:C20493]; Interferon Alpha [NCIT:C20494]; Interferon Beta [NCIT:C20495]; Time Sampled Measurement Datasets [IAO:0000584]; Omics [edam.topic:3391]; Gene expression profile data [edam.data:0928]; BioProject Accession Number [NCIT:C175890]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Data Download [schema:DataDownload]
OSTI Identifier:
1661922
DOI:
https://doi.org/10.25584/LHVIFNaaHUHH0011/1661922

Citation Formats

Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. Omics-Lethal Human Viruses, Interferon-Stimulated Response Experiment IFNaHUH001. United States: N. p., 2021. Web. doi:10.25584/LHVIFNaaHUHH0011/1661922.
Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. Omics-Lethal Human Viruses, Interferon-Stimulated Response Experiment IFNaHUH001. United States. doi:https://doi.org/10.25584/LHVIFNaaHUHH0011/1661922
Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021. "Omics-Lethal Human Viruses, Interferon-Stimulated Response Experiment IFNaHUH001". United States. doi:https://doi.org/10.25584/LHVIFNaaHUHH0011/1661922. https://www.osti.gov/servlets/purl/1661922. Pub date:Mon Jan 18 00:00:00 EST 2021
@article{osti_1661922,
title = {Omics-Lethal Human Viruses, Interferon-Stimulated Response Experiment IFNaHUH001},
author = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},
abstractNote = {The purpose of this experiment was to evaluate the human host cellular response to treatment with and without interferon alpha/beta (IFNα/β) treatment. Sample time course data was obtained from human hepatoma carcinoma cells (HUH-7) expressing transcriptional activation protein VP30, stably transfected with the Ebola VP30 gene for enabling replication of VP30-deficient Ebola virus for transcriptome expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset download have a direct relationship to a primary sample submission corresponding to a specific interferon response to viral infection.},
doi = {10.25584/LHVIFNaaHUHH0011/1661922},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {1}
}

Works referenced in this record:

Replication-Deficient Ebolavirus as a Vaccine Candidate
journal, February 2009


IFNaIHH01
dataset, January 2020


    Works referencing / citing this record: