Ultracompact 3D microfluidics for time-resolved structural biology

doi:10.11577/1601629

Title: Ultracompact 3D microfluidics for time-resolved structural biology

Authors:: Knoška, J

Publication Date:: 2019-12-01

Other Number(s):: CXIDB ID 120

DOE Contract Number:: AC02-05CH11231

Product Type:: Dataset

Research Org.:: Coherent X-ray Imaging Data Bank (Lawrence Berkeley National Laboratory); CFEL, DESY, Stuttgart University

Sponsoring Org.:: CFEL, DESY, Stuttgart University

Keywords:: XFEL; Hemoglobin; X-ray Free-electorn Lasers; Serial Femtosecond Crystallography; MFX; LCLS

OSTI Identifier:: 1601629

DOI:: 10.11577/1601629

Citation Formats


                    Knoška, J. Ultracompact 3D microfluidics for time-resolved structural biology.  United States: N. p., 2019. 
        Web.  doi:10.11577/1601629.

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                    Knoška, J. Ultracompact 3D microfluidics for time-resolved structural biology.  United States.  doi:10.11577/1601629.

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                    Knoška, J. 2019.  
"Ultracompact 3D microfluidics for time-resolved structural biology".  United States.  doi:10.11577/1601629.  https://www.osti.gov/servlets/purl/1601629. Pub date:Sun Dec 01 00:00:00 EST 2019

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@article{osti_1601629,

  title        = {Ultracompact 3D microfluidics for time-resolved structural biology},

  author       = {Knoška, J},

  abstractNote = {},

  doi          = {10.11577/1601629},

  journal      = {},

  number       = ,

  volume       = ,

  place        = {United States},

  year         = {2019},

  month        = {12}

}

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DOI: 10.11577/1601629

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Coherent X-ray Imaging Data Bank (CXIDB)

Maia, Filipe

The Coherent X-ray Imaging Data Bank (CXIDB) is a new database which offers scientists from all over the world a unique opportunity to access data from Coherent X-ray Imaging (CXI) experiments. The main goal of the Coherent X-ray Imaging Data Bank is to create an open repository for CXI experimental data. CXIDB is dedicated to further the goal of making data from Coherent X-ray Imaging (CXI) experiments available to all, as well as archiving it. The website also serves as the reference for the CXI file format, in which most of the experimental data on the database is stored in.

Works referenced in this record:

Ultracompact 3D microfluidics for time-resolved structural biology
journal, January 2020

Knoška, Juraj; Adriano, Luigi; Awel, Salah
Nature Communications, Vol. 11, Issue 1
DOI: 10.1038/s41467-020-14434-6

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Ultracompact 3D microfluidics for time-resolved structural biology

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To advance microfluidic integration, we present the use of two-photon additive manufacturing to fold 2D channel layouts into compact free-form 3D fluidic circuits with nanometer precision. We demonstrate this technique by tailoring microfluidic nozzles and mixers for time-resolved structural biology at X-ray free-electron lasers (XFELs). We achieve submicron jets with speeds exceeding 160 ms-1, which allows for the use of megahertz XFEL repetition rates. By integrating an additional orifice, we implement a low consumption flow-focusing nozzle, which is validated by solving a hemoglobin structure. Also, aberration-free in operando X-ray microtomography is introduced to study efficient equivolumetric millisecond mixing in channelsmore »« less
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Research Org:	Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); National Energy Research Scientific Computing Center (NERSC), Berkeley, CA (United States); Scientific Discovery through Advanced Computing (SciDAC), Oak Ridge, TN (United States)
Sponsoring Org:	USDOE Office of Science (SC), Advanced Scientific Computing Research (ASCR)

Title: Ultracompact 3D microfluidics for time-resolved structural biology

Citation Formats

Ultracompact 3D microfluidics for time-resolved structural biology journal, January 2020

Ultracompact 3D microfluidics for time-resolved structural biology
journal, January 2020