skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Ion Mobility Mass Spectrometry Direct Isotope Abundance Analysis

Abstract

The nuclear forensics community is currently engaged in the analysis of illicit nuclear or radioactive material for the purposes of non-proliferations and attribution. One technique commonly employed for gathering nuclear forensics information is isotope analysis. At present, the state-of-the-art methodology for obtaining isotopic distributions is thermal ionization mass spectrometry (TIMS). Although TIMS is highly accurate at determining isotope distributions, the technique requires an elementally pure sample to perform the measurement. The required radiochemical separations give rise to sample preparation times that can be in excess of one to two weeks. Clearly, the nuclear forensics community is in need of instrumentation and methods that can expedite their decision making process in the event of a radiological release or nuclear detonation. Accordingly, we are developing instrumentation that couples a high resolution IM drift cell to the front end of a MS. The IM cell provides a means of separating ions based upon their collision cross-section and mass-to-charge ratio (m/z). Two analytes with the same m/z, but with different collision cross-sections (shapes) would exit the cell at different times, essentially enabling the cell to function in a similar manner to a gas chromatography (GC) column. Thus, molecular and atomic isobaric interferences can bemore » effectively removed from the ion beam. The mobility selected chemical species could then be introduced to a MS for high-resolution mass analysis to generate isotopic distributions of the target analytes. The outcome would be an IM/MS system capable of accurately measuring isotopic distributions while concurrently eliminating isobaric interferences and laboratory radiochemical sample preparation. The overall objective of this project is developing instrumentation and methods to produce near real-time isotope distributions with a modular mass spectrometric system that performs the required gas-phase chemistry and separations. The system couples a high-resolution ion mobility (IM) drift cell to the front end of a mass spectrometer (MS) allowing for chemical separation prior to isotope distribution analyses. This will yield isotope ratio measurement capabilities with minimal sample preparation.« less

Authors:
Publication Date:
Research Org.:
National Security Technologies, LLC (United States)
Sponsoring Org.:
USDOE; USDOE National Nuclear Security Administration (NA)
OSTI Identifier:
992579
Report Number(s):
DOE/NV/25946-999
TRN: US1100393
DOE Contract Number:  
DE-AC52-06NA25946
Resource Type:
Conference
Resource Relation:
Conference: May 25-27, 2010; NA-22 Joint Program Review at Sandia National Laboratories - Material Production and Weaponization Detection
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; ABUNDANCE; CHEMISTRY; CROSS SECTIONS; DECISION MAKING; DETECTION; DISTRIBUTION; GAS CHROMATOGRAPHY; ION BEAMS; ION MOBILITY; IONIZATION; ISOTOPE RATIO; MASS SPECTROMETERS; MASS SPECTROSCOPY; PRODUCTION; RADIOACTIVE MATERIALS; RESOLUTION; SAMPLE PREPARATION; SANDIA NATIONAL LABORATORIES; TARGETS; ion mobility spectrometry, mass spectrometry, direct isotope

Citation Formats

Manuel J. Manard, Stephan Weeks, Kevin Kyle. Ion Mobility Mass Spectrometry Direct Isotope Abundance Analysis. United States: N. p., 2010. Web.
Manuel J. Manard, Stephan Weeks, Kevin Kyle. Ion Mobility Mass Spectrometry Direct Isotope Abundance Analysis. United States.
Manuel J. Manard, Stephan Weeks, Kevin Kyle. Thu . "Ion Mobility Mass Spectrometry Direct Isotope Abundance Analysis". United States. https://www.osti.gov/servlets/purl/992579.
@article{osti_992579,
title = {Ion Mobility Mass Spectrometry Direct Isotope Abundance Analysis},
author = {Manuel J. Manard, Stephan Weeks, Kevin Kyle},
abstractNote = {The nuclear forensics community is currently engaged in the analysis of illicit nuclear or radioactive material for the purposes of non-proliferations and attribution. One technique commonly employed for gathering nuclear forensics information is isotope analysis. At present, the state-of-the-art methodology for obtaining isotopic distributions is thermal ionization mass spectrometry (TIMS). Although TIMS is highly accurate at determining isotope distributions, the technique requires an elementally pure sample to perform the measurement. The required radiochemical separations give rise to sample preparation times that can be in excess of one to two weeks. Clearly, the nuclear forensics community is in need of instrumentation and methods that can expedite their decision making process in the event of a radiological release or nuclear detonation. Accordingly, we are developing instrumentation that couples a high resolution IM drift cell to the front end of a MS. The IM cell provides a means of separating ions based upon their collision cross-section and mass-to-charge ratio (m/z). Two analytes with the same m/z, but with different collision cross-sections (shapes) would exit the cell at different times, essentially enabling the cell to function in a similar manner to a gas chromatography (GC) column. Thus, molecular and atomic isobaric interferences can be effectively removed from the ion beam. The mobility selected chemical species could then be introduced to a MS for high-resolution mass analysis to generate isotopic distributions of the target analytes. The outcome would be an IM/MS system capable of accurately measuring isotopic distributions while concurrently eliminating isobaric interferences and laboratory radiochemical sample preparation. The overall objective of this project is developing instrumentation and methods to produce near real-time isotope distributions with a modular mass spectrometric system that performs the required gas-phase chemistry and separations. The system couples a high-resolution ion mobility (IM) drift cell to the front end of a mass spectrometer (MS) allowing for chemical separation prior to isotope distribution analyses. This will yield isotope ratio measurement capabilities with minimal sample preparation.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {5}
}

Conference:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this conference proceeding.

Save / Share: