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Title: Rate constants of mass transfer kinetics in reversed phase liquid chromatography

Abstract

The parameters of the kinetics of mass transfer of several n-alkylbenzenes were measured by the method of moments on a series of columns prepared with different samples of the same RPLC packing material having widely different average particle diameters, from 3 to 50 {micro}m. These data were analyzed using the available models, and correlations. The best agreement between experimental and theoretical data was obtained under the assumption that the rate constant for the external mass transfer increases with increasing average particle size, an unexpected conclusion. It was also shown that the interpretation of the relative importance of the roles of pore diffusivity and surface diffusivity in the internal mass transfer kinetics is somewhat ambiguous and that the conclusion to be drawn from experimental results depends on the assumptions made regarding the tortuosity model and the relationship between k{sub ext} and the average particle size.

Authors:
 [1];  [1];  [2];  [3]
  1. University of Tennessee, Knoxville (UTK)
  2. ORNL
  3. University of Tennessee and Rzeszow University of Technology, Poland
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
989572
DOE Contract Number:  
DE-AC05-00OR22725
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIChE Journal; Journal Volume: 51; Journal Issue: 12
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; LIQUID COLUMN CHROMATOGRAPHY; KINETICS; MASS TRANSFER; PARTICLE SIZE; AROMATICS; MATHEMATICAL MODELS

Citation Formats

Hong, Lan, Gritti, Fabrice, Guiochon, Georges A, and Kaczmarski, Krzysztof. Rate constants of mass transfer kinetics in reversed phase liquid chromatography. United States: N. p., 2005. Web. doi:10.1002/aic.10565.
Hong, Lan, Gritti, Fabrice, Guiochon, Georges A, & Kaczmarski, Krzysztof. Rate constants of mass transfer kinetics in reversed phase liquid chromatography. United States. doi:10.1002/aic.10565.
Hong, Lan, Gritti, Fabrice, Guiochon, Georges A, and Kaczmarski, Krzysztof. Thu . "Rate constants of mass transfer kinetics in reversed phase liquid chromatography". United States. doi:10.1002/aic.10565.
@article{osti_989572,
title = {Rate constants of mass transfer kinetics in reversed phase liquid chromatography},
author = {Hong, Lan and Gritti, Fabrice and Guiochon, Georges A and Kaczmarski, Krzysztof},
abstractNote = {The parameters of the kinetics of mass transfer of several n-alkylbenzenes were measured by the method of moments on a series of columns prepared with different samples of the same RPLC packing material having widely different average particle diameters, from 3 to 50 {micro}m. These data were analyzed using the available models, and correlations. The best agreement between experimental and theoretical data was obtained under the assumption that the rate constant for the external mass transfer increases with increasing average particle size, an unexpected conclusion. It was also shown that the interpretation of the relative importance of the roles of pore diffusivity and surface diffusivity in the internal mass transfer kinetics is somewhat ambiguous and that the conclusion to be drawn from experimental results depends on the assumptions made regarding the tortuosity model and the relationship between k{sub ext} and the average particle size.},
doi = {10.1002/aic.10565},
journal = {AIChE Journal},
number = 12,
volume = 51,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 2005},
month = {Thu Dec 01 00:00:00 EST 2005}
}