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Title: Synthetic heparin-binding factor analogs

Patent ·
OSTI ID:989000
 [1];  [2];  [3];  [4]
  1. Poquott, NY
  2. Gaithersburg, MD
  3. Plainview, NY
  4. Shoreham, NY
+ Show Author Affiliations

The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a linker, which may be a hydrophobic linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-98CH10886
Assignee:
BioSurface Engineering Technologies, Inc. (Rockville, MD); Brookhaven Science Associates (Upton, NY)
Patent Number(s):
7,700,563
Application Number:
7,700,563
OSTI ID:
989000
Country of Publication:
United States
Language:
English

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