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Title: Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones

Abstract

The changes in tissue architecture that accompany the development of breast cancer have been the focus of investigations aimed at developing new cancer therapeutics. As we learn more about the normal mammary gland, we have begun to understand the complex signaling pathways underlying the dramatic shifts in the structure and function of breast tissue. Integrin-, growth factor-, and steroid hormone-signaling pathways all play an important part in maintaining tissue architecture; disruption of the delicate balance of signaling results in dramatic changes in the way cells interact with each other and with the extracellular matrix, leading to breast cancer. The extracellular matrix itself plays a central role in coordinating these signaling processes. In this review, we consider the interrelationships between the extracellular matrix, integrins, growth factors, and steroid hormones in mammary gland development and function.

Authors:
;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
Life Sciences Division
OSTI Identifier:
988993
Report Number(s):
LBNL-3944E
Journal ID: 1351-0088; TRN: US201019%%236
DOE Contract Number:  
DE-AC02-05CH11231; DE-AC03-76SF00098, CA-64786 and CA-57621
Resource Type:
Journal Article
Journal Name:
Endocrine-Related Cancer
Additional Journal Information:
Journal Volume: 7; Journal Issue: 2; Related Information: Journal Publication Date: 6/2000
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; GROWTH FACTORS; MAMMARY GLANDS; NEOPLASMS; STEROID HORMONES; STEROIDS; ANIMAL TISSUES

Citation Formats

Hansen, R K, and Bissell, M J. Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones. United States: N. p., 2000. Web. doi:10.1677/erc.0.0070095.
Hansen, R K, & Bissell, M J. Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones. United States. doi:10.1677/erc.0.0070095.
Hansen, R K, and Bissell, M J. Thu . "Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones". United States. doi:10.1677/erc.0.0070095. https://www.osti.gov/servlets/purl/988993.
@article{osti_988993,
title = {Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones},
author = {Hansen, R K and Bissell, M J},
abstractNote = {The changes in tissue architecture that accompany the development of breast cancer have been the focus of investigations aimed at developing new cancer therapeutics. As we learn more about the normal mammary gland, we have begun to understand the complex signaling pathways underlying the dramatic shifts in the structure and function of breast tissue. Integrin-, growth factor-, and steroid hormone-signaling pathways all play an important part in maintaining tissue architecture; disruption of the delicate balance of signaling results in dramatic changes in the way cells interact with each other and with the extracellular matrix, leading to breast cancer. The extracellular matrix itself plays a central role in coordinating these signaling processes. In this review, we consider the interrelationships between the extracellular matrix, integrins, growth factors, and steroid hormones in mammary gland development and function.},
doi = {10.1677/erc.0.0070095},
journal = {Endocrine-Related Cancer},
number = 2,
volume = 7,
place = {United States},
year = {2000},
month = {6}
}