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Methods and compositions for diagnosing and preventing a group B streptococcal infection

Patent ·
OSTI ID:988819
 [1];  [2];  [3];  [4]
  1. Gainesville, FL
  2. Harrisonburg, VA
  3. Memphis, TN
  4. Salt Lake City, UT
+ Show Author Affiliations
The present invention provides a group B streptococcal (GBS) surface antigen, designated epsilon antigen, that is co-expressed with the delta antigen on a subset of serotype III GBS. Epsilon is expressed on more pathogenic Restriction Digest Pattern (RDP) III-3 GBS, but not on RDP types 1, 2, or 4. Accordingly, the present invention provides compositions and methods for detecting a group B streptococcus serotype III, RDP III-3 strain. Vaccines and methods of identifying agents which inhibit adhesion of a group B streptococcal cell to a host cell are also provided.
Research Organization:
St. Jude Children's Research Hospital (Memphis, TN); University of Florida (Gainesville, FL); University of Utah Research Foundation (Salt Lake City, UT)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG05-93ER20097
Assignee:
St. Jude Children's Research Hospital (Memphis, TN); University of Florida (Gainesville, FL); University of Utah Research Foundation (Salt Lake City, UT)
Patent Number(s):
7,588,773
Application Number:
11/574,067
OSTI ID:
988819
Country of Publication:
United States
Language:
English

References (5)

Long-Range Mapping of the Streptococcus agalactiae Phylogenetic Lineage Restriction Digest Pattern Type III-3 Reveals Clustering of Virulence Genes journal January 2002
Identification of a Highly Encapsulated, Genetically Related Group of Invasive Type III Group B Streptococci journal April 1998
beta-Endorphin omission analogs: dissociation of immunoreactivity from other biological activities. journal June 1980
Antibodies Reactive with the N-Terminal Domain ofPlasmodium falciparum Serine Repeat Antigen Inhibit Cell Proliferation by Agglutinating Merozoites and Schizonts journal January 1999
A single amino acid substitution in a common african allele of the CD4 molecule ablates binding of the monoclonal antibody, OKT4 journal November 1991

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60 APPLIED LIFE SCIENCES