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Title: A physiological systems model for iodine for use in radiation protection

Abstract

This paper summarizes the biokinetic database for iodine in the human body and proposes a biokinetic model for use in dose assessments for radioiodine. The model unifies and extends existing physiological systems models describing three subsystems of the iodine cycle in the body: circulating (extrathyroidal) inorganic iodide; thyroidal iodine (trapping and organic binding of iodide, and synthesis, storage, and secretion of thyroid hormones); and extrathyroidal organic iodine. Thyroidal uptake of iodide is described as a function of daily stable iodine intake and requirements for thyroid hormones. Baseline parameter values are developed for adults with typical iodine intakes and hormone requirements. Estimated thyroid doses derived from the baseline parameter values and reference thyroid weights are higher than values predicted by the current model of the International Commission on Radiological Protection (ICRP) for adults for intake of iodine isotopes with half-lives up to a few hours but consistent with ICRP predictions for longer-lived isotopes. For nearly all iodine isotopes, the proposed model yields order-of-magnitude differences from the ICRP s current iodine model for adults for stomach wall, salivary gland, and kidneys. Dose estimates for intravenously injected 131I-labeled thyroid hormones based on the present model differ substantially from current ICRP values for adultmore » patients for some organs, including the thyroid. Subsequent studies will address age-specific biokinetics of iodine, reduction of doses from radioiodine due to thyroid blocking, and effects of dietary iodine levels and thyroid hormone requirements on thyroid doses from radioiodine.« less

Authors:
 [1]
  1. ORNL
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
Work for Others (WFO)
OSTI Identifier:
988717
DOE Contract Number:  
DE-AC05-00OR22725
Resource Type:
Journal Article
Journal Name:
Radiation Research
Additional Journal Information:
Journal Volume: 174; Journal Issue: 4; Journal ID: ISSN 0033-7587
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; IODINE 131; RADIATION PROTECTION; MATHEMATICAL MODELS; PHYSIOLOGY; RADIATION DOSES; THYROID; UPTAKE; STOMACH; SALIVARY GLANDS; KIDNEYS; RADIONUCLIDE KINETICS; Iodine biokinetic model physiological systems radiation protection

Citation Formats

Leggett, Richard Wayne. A physiological systems model for iodine for use in radiation protection. United States: N. p., 2010. Web. doi:10.1667/RR2243.1.
Leggett, Richard Wayne. A physiological systems model for iodine for use in radiation protection. United States. https://doi.org/10.1667/RR2243.1
Leggett, Richard Wayne. 2010. "A physiological systems model for iodine for use in radiation protection". United States. https://doi.org/10.1667/RR2243.1.
@article{osti_988717,
title = {A physiological systems model for iodine for use in radiation protection},
author = {Leggett, Richard Wayne},
abstractNote = {This paper summarizes the biokinetic database for iodine in the human body and proposes a biokinetic model for use in dose assessments for radioiodine. The model unifies and extends existing physiological systems models describing three subsystems of the iodine cycle in the body: circulating (extrathyroidal) inorganic iodide; thyroidal iodine (trapping and organic binding of iodide, and synthesis, storage, and secretion of thyroid hormones); and extrathyroidal organic iodine. Thyroidal uptake of iodide is described as a function of daily stable iodine intake and requirements for thyroid hormones. Baseline parameter values are developed for adults with typical iodine intakes and hormone requirements. Estimated thyroid doses derived from the baseline parameter values and reference thyroid weights are higher than values predicted by the current model of the International Commission on Radiological Protection (ICRP) for adults for intake of iodine isotopes with half-lives up to a few hours but consistent with ICRP predictions for longer-lived isotopes. For nearly all iodine isotopes, the proposed model yields order-of-magnitude differences from the ICRP s current iodine model for adults for stomach wall, salivary gland, and kidneys. Dose estimates for intravenously injected 131I-labeled thyroid hormones based on the present model differ substantially from current ICRP values for adult patients for some organs, including the thyroid. Subsequent studies will address age-specific biokinetics of iodine, reduction of doses from radioiodine due to thyroid blocking, and effects of dietary iodine levels and thyroid hormone requirements on thyroid doses from radioiodine.},
doi = {10.1667/RR2243.1},
url = {https://www.osti.gov/biblio/988717}, journal = {Radiation Research},
issn = {0033-7587},
number = 4,
volume = 174,
place = {United States},
year = {2010},
month = {1}
}