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Title: Hooked differential mobility spectrometry apparatus and method therefore

Abstract

Disclosed are a device and method for improved interfacing of differential mobility spectrometry (DMS) or field asymmetric waveform ion mobility spectrometry (FAIMS) analyzers of substantially planar geometry to subsequent or preceding instrument stages. Interfacing is achieved using curved DMS elements, where a thick ion beam emitted by planar DMS analyzers or injected into them for ion filtering is compressed to the gap median by DMS ion focusing effect in a spatially inhomogeneous electric field. Resulting thinner beams are more effectively transmitted through necessarily constrained conductance limit apertures to subsequent instrument stages operated at a pressure lower than DMS, and/or more effectively injected into planar DMS analyzers. The technology is synergetic with slit apertures, slit aperture/ion funnels, and high-pressure ion funnel interfaces known in the art which allow for increasing cross-sectional area of MS inlets. The invention may be used in integrated analytical platforms, including, e.g., DMS/MS, LC/DMS/MS, and DMS/IMS/MS that could replace and/or enhance current LC/MS methods, e.g., for proteomics research.

Inventors:
 [1];  [1];  [1];  [1]
  1. Richland, WA
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
988295
Patent Number(s):
7,491,930
Application Number:
11/617,889
Assignee:
Battelle Memorial Institute (Richland, WA)
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Shvartsburg, Alexandre A, Tang, Keqi, Ibrahim, Yehia M, and Smith, Richard D. Hooked differential mobility spectrometry apparatus and method therefore. United States: N. p., 2009. Web.
Shvartsburg, Alexandre A, Tang, Keqi, Ibrahim, Yehia M, & Smith, Richard D. Hooked differential mobility spectrometry apparatus and method therefore. United States.
Shvartsburg, Alexandre A, Tang, Keqi, Ibrahim, Yehia M, and Smith, Richard D. 2009. "Hooked differential mobility spectrometry apparatus and method therefore". United States. https://www.osti.gov/servlets/purl/988295.
@article{osti_988295,
title = {Hooked differential mobility spectrometry apparatus and method therefore},
author = {Shvartsburg, Alexandre A and Tang, Keqi and Ibrahim, Yehia M and Smith, Richard D},
abstractNote = {Disclosed are a device and method for improved interfacing of differential mobility spectrometry (DMS) or field asymmetric waveform ion mobility spectrometry (FAIMS) analyzers of substantially planar geometry to subsequent or preceding instrument stages. Interfacing is achieved using curved DMS elements, where a thick ion beam emitted by planar DMS analyzers or injected into them for ion filtering is compressed to the gap median by DMS ion focusing effect in a spatially inhomogeneous electric field. Resulting thinner beams are more effectively transmitted through necessarily constrained conductance limit apertures to subsequent instrument stages operated at a pressure lower than DMS, and/or more effectively injected into planar DMS analyzers. The technology is synergetic with slit apertures, slit aperture/ion funnels, and high-pressure ion funnel interfaces known in the art which allow for increasing cross-sectional area of MS inlets. The invention may be used in integrated analytical platforms, including, e.g., DMS/MS, LC/DMS/MS, and DMS/IMS/MS that could replace and/or enhance current LC/MS methods, e.g., for proteomics research.},
doi = {},
url = {https://www.osti.gov/biblio/988295}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {2}
}

Works referenced in this record:

Comparison of experimental and calculated peak shapes for three cylindrical geometry FAIMS prototypes of differing electrode diameters
journal, March 2005


High-Resolution Field Asymmetric Waveform Ion Mobility Spectrometry Using New Planar Geometry Analyzers
journal, June 2006


Atmospheric pressure ion trapping in a tandem FAIMS-FAIMS coupled to a TOFMS: Studies with electrospray generated gramicidin S ions
journal, December 2001


Modeling the resolution and sensitivity of FAIMS analyses
journal, October 2004


Optimization of the design and operation of FAIMS analyzers
journal, January 2005


Atmospheric pressure ion focusing in a high-field asymmetric waveform ion mobility spectrometer
journal, February 1999