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Title: Bacterial Microcompartments

Abstract

Bacterialmicrocompartments (BMCs) are organelles composed entirely of protein. They promote specific metabolic processes by encapsulatingand colocalizing enzymes with their substrates and cofactors, by protecting vulnerable enzymes in a defined microenvironment, and bysequestering toxic or volatile intermediates. Prototypes of the BMCsare the carboxysomes of autotrophic bacteria. However, structures of similarpolyhedral shape are being discovered in an ever-increasing number of heterotrophic bacteria, where they participate in the utilization ofspecialty carbon and energy sources.Comparative genomics reveals that the potential for this type of compartmentalization is widespread acrossbacterial phyla and suggests that genetic modules encoding BMCs are frequently laterally transferred among bacteria. The diverse functionsof these BMCs suggest that they contribute to metabolic innovation in bacteria in a broad range of environments.

Authors:
; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
Genomics Division
OSTI Identifier:
988072
Report Number(s):
LBNL-3809E
TRN: US201018%%277
DOE Contract Number:  
DE-AC02-05CH11231
Resource Type:
Journal Article
Journal Name:
Annual Review of Microbiology
Additional Journal Information:
Journal Volume: 64; Related Information: Journal Publication Date: October 2010
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BACTERIA; CARBON; CELL CONSTITUENTS; ENERGY SOURCES; ENZYMES; GENETICS; SHAPE; SUBSTRATES; carboxysome, horizontal gene transfer, bacterial organelle, polyhedral bacterial inclusions

Citation Formats

Kerfeld, Cheryl A, Heinhorst, Sabine, and Cannon, Gordon C. Bacterial Microcompartments. United States: N. p., 2010. Web. doi:10.1146/annurev.micro.112408.134211.
Kerfeld, Cheryl A, Heinhorst, Sabine, & Cannon, Gordon C. Bacterial Microcompartments. United States. https://doi.org/10.1146/annurev.micro.112408.134211
Kerfeld, Cheryl A, Heinhorst, Sabine, and Cannon, Gordon C. 2010. "Bacterial Microcompartments". United States. https://doi.org/10.1146/annurev.micro.112408.134211. https://www.osti.gov/servlets/purl/988072.
@article{osti_988072,
title = {Bacterial Microcompartments},
author = {Kerfeld, Cheryl A and Heinhorst, Sabine and Cannon, Gordon C},
abstractNote = {Bacterialmicrocompartments (BMCs) are organelles composed entirely of protein. They promote specific metabolic processes by encapsulatingand colocalizing enzymes with their substrates and cofactors, by protecting vulnerable enzymes in a defined microenvironment, and bysequestering toxic or volatile intermediates. Prototypes of the BMCsare the carboxysomes of autotrophic bacteria. However, structures of similarpolyhedral shape are being discovered in an ever-increasing number of heterotrophic bacteria, where they participate in the utilization ofspecialty carbon and energy sources.Comparative genomics reveals that the potential for this type of compartmentalization is widespread acrossbacterial phyla and suggests that genetic modules encoding BMCs are frequently laterally transferred among bacteria. The diverse functionsof these BMCs suggest that they contribute to metabolic innovation in bacteria in a broad range of environments.},
doi = {10.1146/annurev.micro.112408.134211},
url = {https://www.osti.gov/biblio/988072}, journal = {Annual Review of Microbiology},
number = ,
volume = 64,
place = {United States},
year = {Sat Jun 05 00:00:00 EDT 2010},
month = {Sat Jun 05 00:00:00 EDT 2010}
}