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Title: Site-specific incorporation of redox active amino acids into proteins

Abstract

Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.

Inventors:
 [1];  [2];  [1]
  1. San Diego, CA
  2. La Jolla, CA
Publication Date:
Research Org.:
The Scripps Research Institute (La Jolla, CA)
Sponsoring Org.:
USDOE
OSTI Identifier:
985869
Patent Number(s):
7,494,796
Application Number:
10/965,218
Assignee:
The Scripps Research Institute (La Jolla, CA) OAK
DOE Contract Number:  
FG03-00ER45812
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Alfonta, Lital, Schultz, Peter G, and Zhang, Zhiwen. Site-specific incorporation of redox active amino acids into proteins. United States: N. p., 2009. Web.
Alfonta, Lital, Schultz, Peter G, & Zhang, Zhiwen. Site-specific incorporation of redox active amino acids into proteins. United States.
Alfonta, Lital, Schultz, Peter G, and Zhang, Zhiwen. Tue . "Site-specific incorporation of redox active amino acids into proteins". United States. doi:. https://www.osti.gov/servlets/purl/985869.
@article{osti_985869,
title = {Site-specific incorporation of redox active amino acids into proteins},
author = {Alfonta, Lital and Schultz, Peter G and Zhang, Zhiwen},
abstractNote = {Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 24 00:00:00 EST 2009},
month = {Tue Feb 24 00:00:00 EST 2009}
}

Patent:

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