skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications

Abstract

The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides means for separation and other biotechnology applications involving holding, manipulation, or separation of magnetizable molecular structures and targets. Also disclosed are hybrid magnetic tweezers able to exert approximately 1 nN of force to 4.5 .mu.m magnetic bead. The maximum force was experimentally measured to be .about.900 pN which is in good agreement with theoretical estimations and other measurements. In addition, a new analysis scheme that permits fast real-time position measurement in typical geometry of magnetic tweezers has been developed and described in detail.

Inventors:
 [1];  [2];  [3];  [1];  [4]
  1. El Cerrito, CA
  2. Seoul, KR
  3. (Berkeley, CA)
  4. Berkeley, CA
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
985856
Patent Number(s):
7,474,184
Application Number:
11/355,462
Assignee:
The Regents of the University of California (Oakland, CA) OAK
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Humphries, David E, Hong, Seok-Cheol, Cozzarelli, legal representative, Linda A., Pollard, Martin J, and Cozzarelli, Nicholas R. Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications. United States: N. p., 2009. Web.
Humphries, David E, Hong, Seok-Cheol, Cozzarelli, legal representative, Linda A., Pollard, Martin J, & Cozzarelli, Nicholas R. Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications. United States.
Humphries, David E, Hong, Seok-Cheol, Cozzarelli, legal representative, Linda A., Pollard, Martin J, and Cozzarelli, Nicholas R. Tue . "Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications". United States. https://www.osti.gov/servlets/purl/985856.
@article{osti_985856,
title = {Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications},
author = {Humphries, David E and Hong, Seok-Cheol and Cozzarelli, legal representative, Linda A. and Pollard, Martin J and Cozzarelli, Nicholas R},
abstractNote = {The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides means for separation and other biotechnology applications involving holding, manipulation, or separation of magnetizable molecular structures and targets. Also disclosed are hybrid magnetic tweezers able to exert approximately 1 nN of force to 4.5 .mu.m magnetic bead. The maximum force was experimentally measured to be .about.900 pN which is in good agreement with theoretical estimations and other measurements. In addition, a new analysis scheme that permits fast real-time position measurement in typical geometry of magnetic tweezers has been developed and described in detail.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {1}
}

Patent:

Save / Share: