Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications

Patent · 06 January 2009

OSTI ID:985856

Humphries, David E ^[1]; Hong, Seok-Cheol ^[2]; Pollard, Martin J ^[1]; Cozzarelli, Nicholas R ^[3]

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1. El Cerrito, CA
2. Seoul, KR
3. Berkeley, CA

The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides means for separation and other biotechnology applications involving holding, manipulation, or separation of magnetizable molecular structures and targets. Also disclosed are hybrid magnetic tweezers able to exert approximately 1 nN of force to 4.5 .mu.m magnetic bead. The maximum force was experimentally measured to be .about.900 pN which is in good agreement with theoretical estimations and other measurements. In addition, a new analysis scheme that permits fast real-time position measurement in typical geometry of magnetic tweezers has been developed and described in detail.

• Research Organization: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC03-76SF00098
• Assignee: The Regents of the University of California (Oakland, CA)
• Patent Number(s): 7,474,184
• Application Number: 11/355,462
• OSTI ID: 985856
• Country of Publication: United States
• Language: English

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