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Title: Dielectrophoretic columnar focusing device

Patent ·
OSTI ID:985227

A dielectrophoretic columnar focusing device uses interdigitated microelectrodes to provide a spatially non-uniform electric field in a fluid that generates a dipole within particles in the fluid. The electric field causes the particles to either be attracted to or repelled from regions where the electric field gradient is large, depending on whether the particles are more or less polarizable than the fluid. The particles can thereby be forced into well defined stable paths along the interdigitated microelectrodes. The device can be used for flow cytometry, particle control, and other process applications, including cell counting or other types of particle counting, and for separations in material control.

Research Organization:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC04-94AL85000
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Number(s):
7,713,395
Application Number:
11/401,714
OSTI ID:
985227
Country of Publication:
United States
Language:
English

References (11)

Particle separation by dielectrophoresis journal July 2002
Surface Micromachined Dielectrophoretic Gates for the Front-End Device of a Biodetection System journal January 2006
Development of surface micromachining technologies for microfluidics and bioMEMS conference September 2001
Frequency and Voltage Dependence of the Dielectrophoretic Trapping of Short Lengths of DNA and dCTP in a Nanopipette journal February 2004
Trapping of DNA by dielectrophoresis journal August 2002
Combined field-induced dielectrophoresis and phase separation for manipulating particles in microfluidics journal December 2003
Molecular dielectrophoresis of biopolymers journal January 1994
Orientation and Positioning of DNA Molecules with an Electric Field Technique journal August 2002
Single particle characterization and manipulation by opposite field dielectrophoresis journal November 2002
Electronic manipulation of DNA, proteins, and nanoparticles for potential circuit assembly journal October 2004
Electrodeless Dielectrophoresis of Single- and Double-Stranded DNA journal October 2002

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