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Title: Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams

Abstract

A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.

Inventors:
 [1];  [2];  [3];  [4];  [5]
  1. Yaphank, NY
  2. Rocky Point, NY
  3. Holden, MA
  4. Monteroduni, IT
  5. Shoreham, NY
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
985214
Patent Number(s):
7,746,979
Application Number:
11/884,158
Assignee:
The United States of America as represented by the United States Department of Energy (Washington, DC)
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Dilmanian, F Avraham, Anchel, David J, Gaudette, Glenn, Romanelli, Pantaleo, and Hainfeld, James. Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams. United States: N. p., 2010. Web.
Dilmanian, F Avraham, Anchel, David J, Gaudette, Glenn, Romanelli, Pantaleo, & Hainfeld, James. Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams. United States.
Dilmanian, F Avraham, Anchel, David J, Gaudette, Glenn, Romanelli, Pantaleo, and Hainfeld, James. Tue . "Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams". United States. https://www.osti.gov/servlets/purl/985214.
@article{osti_985214,
title = {Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams},
author = {Dilmanian, F Avraham and Anchel, David J and Gaudette, Glenn and Romanelli, Pantaleo and Hainfeld, James},
abstractNote = {A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {6}
}

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