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Title: Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams

Patent ·
OSTI ID:985214
 [1];  [2];  [3];  [4];  [5]
  1. Yaphank, NY
  2. Rocky Point, NY
  3. Holden, MA
  4. Monteroduni, IT
  5. Shoreham, NY
+ Show Author Affiliations

A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-98CH10886
Assignee:
The United States of America as represented by the United States Department of Energy (Washington, DC)
Patent Number(s):
7,746,979
Application Number:
11/884,158
OSTI ID:
985214
Country of Publication:
United States
Language:
English

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