Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequencydomain and steady state methodologies
Abstract
A technique for measuring broadband nearinfrared absorption spectra of turbid media that uses a combination of frequencydomain and steadystate reflectance methods. Most of the wavelength coverage is provided by a whitelight steadystate measurement, whereas the frequencydomain data are acquired at a few selected wavelengths. Coefficients of absorption and reduced scattering derived from the frequencydomain data are used to calibrate the intensity of the steadystate measurements and to determine the reduced scattering coefficient at all wavelengths in the spectral window of interest. The absorption coefficient spectrum is determined by comparing the steadystate reflectance values with the predictions of diffusion theory, wavelength by wavelength. Absorption spectra of a turbid phantom and of human breast tissue in vivo, derived with the combined frequencydomain and steadystate technique, agree well with expected reference values.
 Inventors:

 Irvine, CA
 Rochester, NY
 Lake Forest, CA
 Costa Mesa, CA
 Publication Date:
 Research Org.:
 Univ. of California (United States)
 Sponsoring Org.:
 USDOE
 OSTI Identifier:
 984515
 Patent Number(s):
 7,428,434
 Application Number:
 10/191,693
 Assignee:
 The Regents of the Univeristy of California (Oakland, CA)
 DOE Contract Number:
 FG0391ER61227
 Resource Type:
 Patent
 Country of Publication:
 United States
 Language:
 English
 Subject:
 47 OTHER INSTRUMENTATION
Citation Formats
Tromberg, Bruce J, Berger, Andrew J, Cerussi, Albert E, Bevilacqua, Frederic, and Jakubowski, Dorota. Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequencydomain and steady state methodologies. United States: N. p., 2008.
Web.
Tromberg, Bruce J, Berger, Andrew J, Cerussi, Albert E, Bevilacqua, Frederic, & Jakubowski, Dorota. Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequencydomain and steady state methodologies. United States.
Tromberg, Bruce J, Berger, Andrew J, Cerussi, Albert E, Bevilacqua, Frederic, and Jakubowski, Dorota. Tue .
"Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequencydomain and steady state methodologies". United States. https://www.osti.gov/servlets/purl/984515.
@article{osti_984515,
title = {Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequencydomain and steady state methodologies},
author = {Tromberg, Bruce J and Berger, Andrew J and Cerussi, Albert E and Bevilacqua, Frederic and Jakubowski, Dorota},
abstractNote = {A technique for measuring broadband nearinfrared absorption spectra of turbid media that uses a combination of frequencydomain and steadystate reflectance methods. Most of the wavelength coverage is provided by a whitelight steadystate measurement, whereas the frequencydomain data are acquired at a few selected wavelengths. Coefficients of absorption and reduced scattering derived from the frequencydomain data are used to calibrate the intensity of the steadystate measurements and to determine the reduced scattering coefficient at all wavelengths in the spectral window of interest. The absorption coefficient spectrum is determined by comparing the steadystate reflectance values with the predictions of diffusion theory, wavelength by wavelength. Absorption spectra of a turbid phantom and of human breast tissue in vivo, derived with the combined frequencydomain and steadystate technique, agree well with expected reference values.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {9}
}
Works referenced in this record:
Improved solutions of the steadystate and the timeresolved diffusion equations for reflectance from a semiinfinite turbid medium
journal, January 1997
 Kienle, Alwin; Patterson, Michael S.
 Journal of the Optical Society of America A, Vol. 14, Issue 1