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Title: Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies

Abstract

A technique for measuring broadband near-infrared absorption spectra of turbid media that uses a combination of frequency-domain and steady-state reflectance methods. Most of the wavelength coverage is provided by a white-light steady-state measurement, whereas the frequency-domain data are acquired at a few selected wavelengths. Coefficients of absorption and reduced scattering derived from the frequency-domain data are used to calibrate the intensity of the steady-state measurements and to determine the reduced scattering coefficient at all wavelengths in the spectral window of interest. The absorption coefficient spectrum is determined by comparing the steady-state reflectance values with the predictions of diffusion theory, wavelength by wavelength. Absorption spectra of a turbid phantom and of human breast tissue in vivo, derived with the combined frequency-domain and steady-state technique, agree well with expected reference values.

Inventors:
 [1];  [2];  [3];  [4];  [1]
  1. Irvine, CA
  2. Rochester, NY
  3. Lake Forest, CA
  4. Costa Mesa, CA
Publication Date:
Research Org.:
Univ. of California (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
984515
Patent Number(s):
7,428,434
Application Number:
10/191,693
Assignee:
The Regents of the Univeristy of California (Oakland, CA)
DOE Contract Number:  
FG03-91ER61227
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Tromberg, Bruce J, Berger, Andrew J, Cerussi, Albert E, Bevilacqua, Frederic, and Jakubowski, Dorota. Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies. United States: N. p., 2008. Web.
Tromberg, Bruce J, Berger, Andrew J, Cerussi, Albert E, Bevilacqua, Frederic, & Jakubowski, Dorota. Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies. United States.
Tromberg, Bruce J, Berger, Andrew J, Cerussi, Albert E, Bevilacqua, Frederic, and Jakubowski, Dorota. Tue . "Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies". United States. https://www.osti.gov/servlets/purl/984515.
@article{osti_984515,
title = {Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies},
author = {Tromberg, Bruce J and Berger, Andrew J and Cerussi, Albert E and Bevilacqua, Frederic and Jakubowski, Dorota},
abstractNote = {A technique for measuring broadband near-infrared absorption spectra of turbid media that uses a combination of frequency-domain and steady-state reflectance methods. Most of the wavelength coverage is provided by a white-light steady-state measurement, whereas the frequency-domain data are acquired at a few selected wavelengths. Coefficients of absorption and reduced scattering derived from the frequency-domain data are used to calibrate the intensity of the steady-state measurements and to determine the reduced scattering coefficient at all wavelengths in the spectral window of interest. The absorption coefficient spectrum is determined by comparing the steady-state reflectance values with the predictions of diffusion theory, wavelength by wavelength. Absorption spectra of a turbid phantom and of human breast tissue in vivo, derived with the combined frequency-domain and steady-state technique, agree well with expected reference values.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {9}
}

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Works referenced in this record:

Improved solutions of the steady-state and the time-resolved diffusion equations for reflectance from a semi-infinite turbid medium
journal, January 1997

  • Kienle, Alwin; Patterson, Michael S.
  • Journal of the Optical Society of America A, Vol. 14, Issue 1
  • DOI: 10.1364/JOSAA.14.000246