Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis

Pines, Alexander; Budinger, Thomas; Navon, Gil; Song, Yi-Qiao; Appelt, Stephan; Bifone, Angelo; Taylor, Rebecca; Goodson, Boyd; Seydoux, Roberto; Room, Toomas; Pietrass, Tanja

Title: Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis

Patent · Tue Jun 10 00:00:00 EDT 2008

OSTI ID:983068

Pines, Alexander ^[1]; Budinger, Thomas ^[1]; Navon, Gil ^[2]; Song, Yi-Qiao ^[1]; Appelt, Stephan ^[3]; Bifone, Angelo ^[4]; Taylor, Rebecca ^[1]; Goodson, Boyd ^[1]; Seydoux, Roberto ^[1]; Room, Toomas ^[5]; Pietrass, Tanja ^[6]

Berkeley, CA
Ramat Gan, IL
Waiblingen, DE
Rome, IT
Albany, CA
Socorro, NM

The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC03-76SF00098

Assignee:: University of California

Patent Number(s):: 7,385,395

Application Number:: 10/940,297

OSTI ID:: 983068

Country of Publication:: United States

Language:: English

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