Targeted polypeptide degradation

Church, George M; Janse, Daniel M

Targeted polypeptide degradation

Patent · 13 May 2008

OSTI ID:983006

Church, George M ^[1]; Janse, Daniel M ^[1]

Brookline, MA

This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.

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Research Organization:: Harvard University

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-87ER60565

Assignee:: President and Fellows of Harvard College (Cambridge, MA)

Patent Number(s):: 7,371,539

Application Number:: 11/003,103

OSTI ID:: 983006

Country of Publication:: United States

Language:: English

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