Surface Ionization and Soft Landing Techniques in Mass Spectrometry

Book · Thu Apr 01 00:00:00 EDT 2010

OSTI ID:982957

Futrell, Jean H; Laskin, Julia

The advent of soft ionization techniques, notably electrospray and laser desorption ionization methods, has extended mass spectrometric methods to large molecules and molecular complexes. This both greatly expands appli¬cations of mass spectrometry and makes the activation and dissociation of complex ions an integral part of large molecule mass spectrometry. A corollary of the much greater number of internal degrees of freedom and high density of states associated with molecular complexity is that internal energies much higher than the dissociation energies for competing fragmentation processes are required for observable fragmentation in time scales sampled by mass spectrometers. This article describes the kinetics of surface-induced dissociation (SID), a particularly efficient activation method for complex ions. Two very important characteristics of SID are very rapid, sub-picosecond activation and precise control of ion internal energy by varying ion collision energy. The nature of the surface plays an important role in SID, determining both efficiency and mechanism of ion activation. Surface composition and morphology strongly influence the relative importance of competing reactions of SID, ion capture (soft-landing), surface reaction and neutralization. The important features of SID and ion soft-landing are described briefly in this review and more fully in the recommended reading list.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 982957
• Report Number(s): PNNL-SA-71425; 19594; 6291; KC0302020; TRN: US1004333
• Resource Relation: Related Information: Encyclopedia of Spectroscopy and Spectrometry, 2nd Edition, 2778-2787
• Country of Publication: United States
• Language: English

Related Subjects

74 ATOMIC AND MOLECULAR PHYSICS
DEGREES OF FREEDOM
DESORPTION
DISSOCIATION
EFFICIENCY
FRAGMENTATION
ION COLLISIONS
IONIZATION
KINETICS
LASERS
MASS SPECTROMETERS
MASS SPECTROSCOPY
MORPHOLOGY
SURFACE IONIZATION
Complex ions
FT-ICR mass spectrometry
Multiple collision activation
Soft landing
Surface-induced dissociation
Environmental Molecular Sciences Laboratory