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Title: Method for producing a thin sample band in a microchannel device

Abstract

The present invention improves the performance of microchannel systems for chemical and biological synthesis and analysis by providing a method and apparatus for producing a thin band of a species sample. Thin sample bands improve the resolution of microchannel separation processes, as well as many other processes requiring precise control of sample size and volume. The new method comprises a series of steps in which a species sample is manipulated by controlled transport through a junction formed at the intersection of four or more channels. A sample is first inserted into the end of one of these channels in the vicinity of the junction. Next, this sample is thinned by transport across the junction one or more times. During these thinning steps, flow enters the junction through one of the channels and exists through those remaining, providing a divergent flow field that progressively stretches and thins the band with each traverse of the junction. The thickness of the resulting sample band may be smaller than the channel width. Moreover, the thickness of the band may be varied and controlled by altering the method alone, without modification to the channel or junction geometries. The invention is applicable to both electroosmotic andmore » electrophoretic transport, to combined electrokinetic transport, and to some special cases in which bulk fluid transport is driven by pressure gradients. It is further applicable to channels that are open, filled with a gel or filled with a porous or granular material.« less

Inventors:
 [1];  [2]
  1. Livermore, CA
  2. Cardiff, CA
Publication Date:
Research Org.:
Sandia National Laboratories (SNL-CA), Livermore, CA
Sponsoring Org.:
USDOE
OSTI Identifier:
982797
Patent Number(s):
6,770,182
Application Number:
09/714,410
Assignee:
Sandia National Laboratories (Livermore, CA)
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Griffiths, Stewart K, and Nilson, Robert H. Method for producing a thin sample band in a microchannel device. United States: N. p., 2004. Web.
Griffiths, Stewart K, & Nilson, Robert H. Method for producing a thin sample band in a microchannel device. United States.
Griffiths, Stewart K, and Nilson, Robert H. Tue . "Method for producing a thin sample band in a microchannel device". United States. https://www.osti.gov/servlets/purl/982797.
@article{osti_982797,
title = {Method for producing a thin sample band in a microchannel device},
author = {Griffiths, Stewart K and Nilson, Robert H},
abstractNote = {The present invention improves the performance of microchannel systems for chemical and biological synthesis and analysis by providing a method and apparatus for producing a thin band of a species sample. Thin sample bands improve the resolution of microchannel separation processes, as well as many other processes requiring precise control of sample size and volume. The new method comprises a series of steps in which a species sample is manipulated by controlled transport through a junction formed at the intersection of four or more channels. A sample is first inserted into the end of one of these channels in the vicinity of the junction. Next, this sample is thinned by transport across the junction one or more times. During these thinning steps, flow enters the junction through one of the channels and exists through those remaining, providing a divergent flow field that progressively stretches and thins the band with each traverse of the junction. The thickness of the resulting sample band may be smaller than the channel width. Moreover, the thickness of the band may be varied and controlled by altering the method alone, without modification to the channel or junction geometries. The invention is applicable to both electroosmotic and electrophoretic transport, to combined electrokinetic transport, and to some special cases in which bulk fluid transport is driven by pressure gradients. It is further applicable to channels that are open, filled with a gel or filled with a porous or granular material.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {8}
}

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Works referenced in this record:

Computer Simulations of Electrokinetic Injection Techniques in Microfluidic Devices
journal, August 2000

  • Ermakov, Sergey V.; Jacobson, Stephen C.; Ramsey, J. Michael
  • Analytical Chemistry, Vol. 72, Issue 15
  • DOI: 10.1021/ac991474n