Design and Optimization of Renin Inhibitors: Orally Bioavailable Alkyl Amines
Journal Article
·
· Bioorganic and Medicinal Chemistry Letters
Structure-based drug design led to the identification of a novel class of potent, low MW alkylamine renin inhibitors. Oral administration of lead compound 21l, with MW of 508 and IC{sub 50} of 0.47 nM, caused a sustained reduction in mean arterial blood pressure in a double transgenic rat model of hypertension.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source
- Sponsoring Organization:
- Doe - Office Of Science
- DOE Contract Number:
- DE-AC02-98CH10886
- OSTI ID:
- 980136
- Report Number(s):
- BNL-93054-2010-JA; TRN: US201015%%1521
- Journal Information:
- Bioorganic and Medicinal Chemistry Letters, Vol. 19, Issue 13; ISSN 0968-0896
- Country of Publication:
- United States
- Language:
- English
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