Aminopiperidine-Fused Imidazoles as Dipeptidyl Peptidase-IV Inhibitors
Journal Article
·
· Bioorganic and Medicinal Chemistry Letters
A new series of DPP-4 inhibitors derived from piperidine-fused benzimidazoles and imidazopyridines is described. Optimization of this class of DPP-4 inhibitors led to the discovery of imidazopyridine 34. The potency, selectivity, cross-species DMPK profiles, and in vivo efficacy of 34 is reported.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source
- Sponsoring Organization:
- Doe - Office Of Science
- DOE Contract Number:
- DE-AC02-98CH10886
- OSTI ID:
- 980003
- Report Number(s):
- BNL-92921-2010-JA; TRN: US201015%%1388
- Journal Information:
- Bioorganic and Medicinal Chemistry Letters, Vol. 19, Issue 15; ISSN 0968-0896
- Country of Publication:
- United States
- Language:
- English
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