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Title: Site specific biochemical functionalization along the height ov vertically aligned carbon nanofiber arrays

Abstract

Flexible strategies for the biochemical functionalization of synthetic nanoscale materials can enhance their impact upon a broader range of devices and applications. Here we report approaches for the heterogeneous functionalization of vertically aligned carbon nanofibers, a nanostructured material increasingly used to provide nanoscale components in microfabricated devices. Photoresist blocking strategies are developed for site-specific physical, chemical, and electrochemical functionalization of nanofiber arrays both spatially across regions of the device as well as along the length of the vertical nanofibers. These approaches are explored for the functionalization of nanofiber surfaces with gold, conductive polymers, and DNA and for the biotinylation and subsequent capture of active enzyme- and quantum-dot-conjugated (strept)avidins. Functionalizations are visualized with both fluorescent and electron microscopy and characterized using dye and enzyme assays.

Authors:
 [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1]
  1. ORNL
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
Sponsoring Org.:
Work for Others (WFO)
OSTI Identifier:
978259
DOE Contract Number:  
DE-AC05-00OR22725
Resource Type:
Journal Article
Journal Name:
Chemistry of Materials
Additional Journal Information:
Journal Volume: 18; Journal Issue: 14; Journal ID: ISSN 0897-4756
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; CARBON; DNA; DYES; ELECTRON MICROSCOPY; ENZYMES; GOLD; POLYMERS

Citation Formats

McKnight, Timothy E, Peeraphatdit, Chorthip, Jones, Stephen W, Fowlkes, Jason Davidson, Fletcher, Benjamin L, Klein, Kate L, Melechko, Anatoli Vasilievich, Doktycz, Mitchel John, and Simpson, Michael L. Site specific biochemical functionalization along the height ov vertically aligned carbon nanofiber arrays. United States: N. p., 2006. Web. doi:10.1021/cm052680g.
McKnight, Timothy E, Peeraphatdit, Chorthip, Jones, Stephen W, Fowlkes, Jason Davidson, Fletcher, Benjamin L, Klein, Kate L, Melechko, Anatoli Vasilievich, Doktycz, Mitchel John, & Simpson, Michael L. Site specific biochemical functionalization along the height ov vertically aligned carbon nanofiber arrays. United States. https://doi.org/10.1021/cm052680g
McKnight, Timothy E, Peeraphatdit, Chorthip, Jones, Stephen W, Fowlkes, Jason Davidson, Fletcher, Benjamin L, Klein, Kate L, Melechko, Anatoli Vasilievich, Doktycz, Mitchel John, and Simpson, Michael L. 2006. "Site specific biochemical functionalization along the height ov vertically aligned carbon nanofiber arrays". United States. https://doi.org/10.1021/cm052680g.
@article{osti_978259,
title = {Site specific biochemical functionalization along the height ov vertically aligned carbon nanofiber arrays},
author = {McKnight, Timothy E and Peeraphatdit, Chorthip and Jones, Stephen W and Fowlkes, Jason Davidson and Fletcher, Benjamin L and Klein, Kate L and Melechko, Anatoli Vasilievich and Doktycz, Mitchel John and Simpson, Michael L},
abstractNote = {Flexible strategies for the biochemical functionalization of synthetic nanoscale materials can enhance their impact upon a broader range of devices and applications. Here we report approaches for the heterogeneous functionalization of vertically aligned carbon nanofibers, a nanostructured material increasingly used to provide nanoscale components in microfabricated devices. Photoresist blocking strategies are developed for site-specific physical, chemical, and electrochemical functionalization of nanofiber arrays both spatially across regions of the device as well as along the length of the vertical nanofibers. These approaches are explored for the functionalization of nanofiber surfaces with gold, conductive polymers, and DNA and for the biotinylation and subsequent capture of active enzyme- and quantum-dot-conjugated (strept)avidins. Functionalizations are visualized with both fluorescent and electron microscopy and characterized using dye and enzyme assays.},
doi = {10.1021/cm052680g},
url = {https://www.osti.gov/biblio/978259}, journal = {Chemistry of Materials},
issn = {0897-4756},
number = 14,
volume = 18,
place = {United States},
year = {Sat Jul 01 00:00:00 EDT 2006},
month = {Sat Jul 01 00:00:00 EDT 2006}
}