Manipulation of magnetic carriers for drug delivery using pulsed-current high T{sub c} superconductors.
An innovative method of manipulating magnetic carriers is proposed, and its feasibility for drug delivery and therapy is demonstrated experimentally. The proposed method employs pulsed-field solenoid coils with high-critical-temperature (T{sub c}) superconductor inserts. Pulsed current is used to magnetize and de-magnetize the superconductor insert. The proposed method was demonstrated to be able to (1) move magnetic particles, ranging in size from a few millimeters to 10 {micro}m, with strong enough forces over a substantial distance, (2) hold the particles at a designated position as long as needed, and (3) reverse the processes and retrieve the particles. We further demonstrated that magnetic particles can be manipulated in a stationary environment, in water flow, and in simulated blood (water/glycerol mixture) flow.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC)
- DOE Contract Number:
- DE-AC02-06CH11357
- OSTI ID:
- 971453
- Report Number(s):
- ANL/MSD/CP-58076; TRN: US201004%%16
- Journal Information:
- J. Magn. Magn. Mater. (Special Issue), Vol. 311, Issue 1 ; 2007; Conference: 6th International Conference on Scientific andf Clinical Applications of Magnetic Carriers; May 17, 2006 - May 20, 2006; Krems, Austria
- Country of Publication:
- United States
- Language:
- ENGLISH
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