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Title: Structure-based receptor MIMICS targeted against bacterial superantigen toxins

Patent ·
OSTI ID:968328
 [1];  [2];  [2];  [3]
  1. Santa Fe, NM
  2. Los Alamos, NM
  3. Albuquerque, NM
+ Show Author Affiliations

The invention provides therapeutic compositions useful in the treatment of bacterial superantigen mediated conditions, such as Toxic Shock Syndrome. The compositions comprise genetically engineered bifunctional polypeptides containing a specific T-cell receptor binding domain and a specific MHC class II receptor binding domain, each targeting non-overlapping epitopes on a superantigen molecule against which they are designed. The anti-superantigen "receptor mimetics" or "chimeras" are rationally designed to recreate the modality of superantigen binding directly to both the TCR and the MHC-II receptor, and are capable of acting as decoys for superantigen binding, effectively out-competing the host T-cell and MHC-II receptors, the natural host receptors.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
W-7405-ENG-36
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Number(s):
7,576,183
Application Number:
10/746,959
OSTI ID:
968328
Country of Publication:
United States
Language:
English

References (43)

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