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Title: Glucose Biosensor Based on Immobilization of Glucose Oxidase in Platinum Nanoparticles/Graphene/Chitosan Nanocomposite Film

Abstract

The bionanocomposite film consisting of glucose oxidase/Pt/functional graphene sheets/chitosan (GOD/Pt/FGS/chitosan) for glucose sensing was described. With the electrocatalytic synergy of FGS and Pt nanoparticles to hydrogen peroxide, a sensitive biosensor with detection limit of 0.6 µM glucose was achieved. The biosensor also had good reproducibility, long term stability and negligible interfering signals from ascorbic acid and uric acid comparing to the response to glucose. The large surface area and good conductivity of graphene suggests that graphene is a potential candidate for sensor material. The hybrid nanocomposite glucose sensor provides new opportunity for clinical diagnosis and point-of-care applications.

Authors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
Sponsoring Org.:
USDOE
OSTI Identifier:
965582
Report Number(s):
PNNL-SA-67022
Journal ID: ISSN 0039-9140; TLNTA2; 30493; TRN: US200920%%351
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Talanta, 80(1):403-406
Additional Journal Information:
Journal Volume: 80; Journal Issue: 1; Journal ID: ISSN 0039-9140
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; GLUCOSE; BIOLOGICAL INDICATORS; OXIDASES; IMMOBILIZED CELLS; PLATINUM; NANOSTRUCTURES; FILMS; COMPOSITE MATERIALS; SENSORS; PERFORMANCE; Graphene; Pt nanoparticle; biosensor; Environmental Molecular Sciences Laboratory

Citation Formats

Wu, Hong, Wang, Jun, Kang, Xinhuang, Wang, Chong M, Wang, Donghai, Liu, Jun, Aksay, Ilhan A, and Lin, Yuehe. Glucose Biosensor Based on Immobilization of Glucose Oxidase in Platinum Nanoparticles/Graphene/Chitosan Nanocomposite Film. United States: N. p., 2009. Web. doi:10.1016/j.talanta.2009.06.054.
Wu, Hong, Wang, Jun, Kang, Xinhuang, Wang, Chong M, Wang, Donghai, Liu, Jun, Aksay, Ilhan A, & Lin, Yuehe. Glucose Biosensor Based on Immobilization of Glucose Oxidase in Platinum Nanoparticles/Graphene/Chitosan Nanocomposite Film. United States. https://doi.org/10.1016/j.talanta.2009.06.054
Wu, Hong, Wang, Jun, Kang, Xinhuang, Wang, Chong M, Wang, Donghai, Liu, Jun, Aksay, Ilhan A, and Lin, Yuehe. 2009. "Glucose Biosensor Based on Immobilization of Glucose Oxidase in Platinum Nanoparticles/Graphene/Chitosan Nanocomposite Film". United States. https://doi.org/10.1016/j.talanta.2009.06.054.
@article{osti_965582,
title = {Glucose Biosensor Based on Immobilization of Glucose Oxidase in Platinum Nanoparticles/Graphene/Chitosan Nanocomposite Film},
author = {Wu, Hong and Wang, Jun and Kang, Xinhuang and Wang, Chong M and Wang, Donghai and Liu, Jun and Aksay, Ilhan A and Lin, Yuehe},
abstractNote = {The bionanocomposite film consisting of glucose oxidase/Pt/functional graphene sheets/chitosan (GOD/Pt/FGS/chitosan) for glucose sensing was described. With the electrocatalytic synergy of FGS and Pt nanoparticles to hydrogen peroxide, a sensitive biosensor with detection limit of 0.6 µM glucose was achieved. The biosensor also had good reproducibility, long term stability and negligible interfering signals from ascorbic acid and uric acid comparing to the response to glucose. The large surface area and good conductivity of graphene suggests that graphene is a potential candidate for sensor material. The hybrid nanocomposite glucose sensor provides new opportunity for clinical diagnosis and point-of-care applications.},
doi = {10.1016/j.talanta.2009.06.054},
url = {https://www.osti.gov/biblio/965582}, journal = {Talanta, 80(1):403-406},
issn = {0039-9140},
number = 1,
volume = 80,
place = {United States},
year = {Tue Sep 01 00:00:00 EDT 2009},
month = {Tue Sep 01 00:00:00 EDT 2009}
}