Glucose Biosensor Based on Immobilization of Glucose Oxidase in Platinum Nanoparticles/Graphene/Chitosan Nanocomposite Film
Abstract
The bionanocomposite film consisting of glucose oxidase/Pt/functional graphene sheets/chitosan (GOD/Pt/FGS/chitosan) for glucose sensing was described. With the electrocatalytic synergy of FGS and Pt nanoparticles to hydrogen peroxide, a sensitive biosensor with detection limit of 0.6 µM glucose was achieved. The biosensor also had good reproducibility, long term stability and negligible interfering signals from ascorbic acid and uric acid comparing to the response to glucose. The large surface area and good conductivity of graphene suggests that graphene is a potential candidate for sensor material. The hybrid nanocomposite glucose sensor provides new opportunity for clinical diagnosis and point-of-care applications.
- Authors:
- Publication Date:
- Research Org.:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 965582
- Report Number(s):
- PNNL-SA-67022
Journal ID: ISSN 0039-9140; TLNTA2; 30493; TRN: US200920%%351
- DOE Contract Number:
- AC05-76RL01830
- Resource Type:
- Journal Article
- Journal Name:
- Talanta, 80(1):403-406
- Additional Journal Information:
- Journal Volume: 80; Journal Issue: 1; Journal ID: ISSN 0039-9140
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; GLUCOSE; BIOLOGICAL INDICATORS; OXIDASES; IMMOBILIZED CELLS; PLATINUM; NANOSTRUCTURES; FILMS; COMPOSITE MATERIALS; SENSORS; PERFORMANCE; Graphene; Pt nanoparticle; biosensor; Environmental Molecular Sciences Laboratory
Citation Formats
Wu, Hong, Wang, Jun, Kang, Xinhuang, Wang, Chong M, Wang, Donghai, Liu, Jun, Aksay, Ilhan A, and Lin, Yuehe. Glucose Biosensor Based on Immobilization of Glucose Oxidase in Platinum Nanoparticles/Graphene/Chitosan Nanocomposite Film. United States: N. p., 2009.
Web. doi:10.1016/j.talanta.2009.06.054.
Wu, Hong, Wang, Jun, Kang, Xinhuang, Wang, Chong M, Wang, Donghai, Liu, Jun, Aksay, Ilhan A, & Lin, Yuehe. Glucose Biosensor Based on Immobilization of Glucose Oxidase in Platinum Nanoparticles/Graphene/Chitosan Nanocomposite Film. United States. https://doi.org/10.1016/j.talanta.2009.06.054
Wu, Hong, Wang, Jun, Kang, Xinhuang, Wang, Chong M, Wang, Donghai, Liu, Jun, Aksay, Ilhan A, and Lin, Yuehe. 2009.
"Glucose Biosensor Based on Immobilization of Glucose Oxidase in Platinum Nanoparticles/Graphene/Chitosan Nanocomposite Film". United States. https://doi.org/10.1016/j.talanta.2009.06.054.
@article{osti_965582,
title = {Glucose Biosensor Based on Immobilization of Glucose Oxidase in Platinum Nanoparticles/Graphene/Chitosan Nanocomposite Film},
author = {Wu, Hong and Wang, Jun and Kang, Xinhuang and Wang, Chong M and Wang, Donghai and Liu, Jun and Aksay, Ilhan A and Lin, Yuehe},
abstractNote = {The bionanocomposite film consisting of glucose oxidase/Pt/functional graphene sheets/chitosan (GOD/Pt/FGS/chitosan) for glucose sensing was described. With the electrocatalytic synergy of FGS and Pt nanoparticles to hydrogen peroxide, a sensitive biosensor with detection limit of 0.6 µM glucose was achieved. The biosensor also had good reproducibility, long term stability and negligible interfering signals from ascorbic acid and uric acid comparing to the response to glucose. The large surface area and good conductivity of graphene suggests that graphene is a potential candidate for sensor material. The hybrid nanocomposite glucose sensor provides new opportunity for clinical diagnosis and point-of-care applications.},
doi = {10.1016/j.talanta.2009.06.054},
url = {https://www.osti.gov/biblio/965582},
journal = {Talanta, 80(1):403-406},
issn = {0039-9140},
number = 1,
volume = 80,
place = {United States},
year = {Tue Sep 01 00:00:00 EDT 2009},
month = {Tue Sep 01 00:00:00 EDT 2009}
}
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