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Title: Sentra : a database of signal transduction proteins for comparative genome analysis.

Abstract

Sentra (http://compbio.mcs.anl.gov/sentra), a database of signal transduction proteins encoded in completely sequenced prokaryotic genomes, has been updated to reflect recent advances in understanding signal transduction events on a whole-genome scale. Sentra consists of two principal components, a manually curated list of signal transduction proteins in 202 completely sequenced prokaryotic genomes and an automatically generated listing of predicted signaling proteins in 235 sequenced genomes that are awaiting manual curation. In addition to two-component histidine kinases and response regulators, the database now lists manually curated Ser/Thr/Tyr protein kinases and protein phosphatases, as well as adenylate and diguanylate cyclases and c-di-GMP phosphodiesterases, as defined in several recent reviews. All entries in Sentra are extensively annotated with relevant information from public databases (e.g. UniProt, KEGG, PDB and NCBI). Sentra's infrastructure was redesigned to support interactive cross-genome comparisons of signal transduction capabilities of prokaryotic organisms from a taxonomic and phenotypic perspective and in the framework of signal transduction pathways from KEGG. Sentra leverages the PUMA2 system to support interactive analysis and annotation of signal transduction proteins by the users.

Authors:
; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC); National Institutes of Health (NIH); GLRCE
OSTI Identifier:
962543
Report Number(s):
ANL/MCS/JA-57931
Journal ID: ISSN 0305-1048; NARHAD; TRN: US200916%%114
DOE Contract Number:  
DE-AC02-06CH11357
Resource Type:
Journal Article
Resource Relation:
Journal Name: Nucleic Acids Res.; Journal Volume: 35; Journal Issue: Jan. 2007
Country of Publication:
United States
Language:
ENGLISH
Subject:
59 BASIC BIOLOGICAL SCIENCES; CYCLASES; HISTIDINE; PHOSPHATASES; PHOSPHODIESTERASES; PHOSPHOTRANSFERASES; PROTEINS

Citation Formats

D'Souza, M., Glass, E. M., Syed, M. H., Zhang, Y., Rodriguez, A., Maltsev, N., Galerpin, M. Y., Mathematics and Computer Science, Univ. of Chicago, and NIH. Sentra : a database of signal transduction proteins for comparative genome analysis.. United States: N. p., 2007. Web. doi:10.1093/nar/gkl949.
D'Souza, M., Glass, E. M., Syed, M. H., Zhang, Y., Rodriguez, A., Maltsev, N., Galerpin, M. Y., Mathematics and Computer Science, Univ. of Chicago, & NIH. Sentra : a database of signal transduction proteins for comparative genome analysis.. United States. doi:10.1093/nar/gkl949.
D'Souza, M., Glass, E. M., Syed, M. H., Zhang, Y., Rodriguez, A., Maltsev, N., Galerpin, M. Y., Mathematics and Computer Science, Univ. of Chicago, and NIH. Mon . "Sentra : a database of signal transduction proteins for comparative genome analysis.". United States. doi:10.1093/nar/gkl949.
@article{osti_962543,
title = {Sentra : a database of signal transduction proteins for comparative genome analysis.},
author = {D'Souza, M. and Glass, E. M. and Syed, M. H. and Zhang, Y. and Rodriguez, A. and Maltsev, N. and Galerpin, M. Y. and Mathematics and Computer Science and Univ. of Chicago and NIH},
abstractNote = {Sentra (http://compbio.mcs.anl.gov/sentra), a database of signal transduction proteins encoded in completely sequenced prokaryotic genomes, has been updated to reflect recent advances in understanding signal transduction events on a whole-genome scale. Sentra consists of two principal components, a manually curated list of signal transduction proteins in 202 completely sequenced prokaryotic genomes and an automatically generated listing of predicted signaling proteins in 235 sequenced genomes that are awaiting manual curation. In addition to two-component histidine kinases and response regulators, the database now lists manually curated Ser/Thr/Tyr protein kinases and protein phosphatases, as well as adenylate and diguanylate cyclases and c-di-GMP phosphodiesterases, as defined in several recent reviews. All entries in Sentra are extensively annotated with relevant information from public databases (e.g. UniProt, KEGG, PDB and NCBI). Sentra's infrastructure was redesigned to support interactive cross-genome comparisons of signal transduction capabilities of prokaryotic organisms from a taxonomic and phenotypic perspective and in the framework of signal transduction pathways from KEGG. Sentra leverages the PUMA2 system to support interactive analysis and annotation of signal transduction proteins by the users.},
doi = {10.1093/nar/gkl949},
journal = {Nucleic Acids Res.},
number = Jan. 2007,
volume = 35,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}