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Title: Functional Insights from Structural Genomics

Abstract

Structural genomics efforts have produced structural information, either directly or by modeling, for thousands of proteins over the past few years. While many of these proteins have known functions, a large percentage of them have not been characterized at the functional level. The structural information has provided valuable functional insights on some of these proteins, through careful structural analyses, serendipity, and structure-guided functional screening. Some of the success stories based on structures solved at the Northeast Structural Genomics Consortium (NESG) are reported here. These include a novel methyl salicylate esterase with important role in plant innate immunity, a novel RNA methyltransferase (H. influenzae yggJ (HI0303)), a novel spermidine/spermine N-acetyltransferase (B. subtilis PaiA), a novel methyltransferase or AdoMet binding protein (A. fulgidus AF{_}0241), an ATP:cob(I)alamin adenosyltransferase (B. subtilis YvqK), a novel carboxysome pore (E. coli EutN), a proline racemase homolog with a disrupted active site (B. melitensis BME11586), an FMN-dependent enzyme (S. pneumoniae SP{_}1951), and a 12-stranded {beta}-barrel with a novel fold (V. parahaemolyticus VPA1032).

Authors:
; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL) National Synchrotron Light Source
Sponsoring Org.:
Doe - Office Of Science
OSTI Identifier:
960066
Report Number(s):
BNL-83052-2009-JA
TRN: US201016%%1210
DOE Contract Number:  
DE-AC02-98CH10886
Resource Type:
Journal Article
Journal Name:
Journal of Structural and Functional Genomics
Additional Journal Information:
Journal Volume: 8
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; ENZYMES; ESTERASES; FUNCTIONALS; IMMUNITY; PROLINE; PROTEINS; RNA; SIMULATION; GENES; national synchrotron light source

Citation Formats

Forouhar,F., Kuzin, A., Seetharaman, J., Lee, I., Zhou, W., Abashidze, M., Chen, Y., Montelione, G., Tong, L., and et al. Functional Insights from Structural Genomics. United States: N. p., 2007. Web. doi:10.1007/s10969-007-9018-3.
Forouhar,F., Kuzin, A., Seetharaman, J., Lee, I., Zhou, W., Abashidze, M., Chen, Y., Montelione, G., Tong, L., & et al. Functional Insights from Structural Genomics. United States. doi:10.1007/s10969-007-9018-3.
Forouhar,F., Kuzin, A., Seetharaman, J., Lee, I., Zhou, W., Abashidze, M., Chen, Y., Montelione, G., Tong, L., and et al. Mon . "Functional Insights from Structural Genomics". United States. doi:10.1007/s10969-007-9018-3.
@article{osti_960066,
title = {Functional Insights from Structural Genomics},
author = {Forouhar,F. and Kuzin, A. and Seetharaman, J. and Lee, I. and Zhou, W. and Abashidze, M. and Chen, Y. and Montelione, G. and Tong, L. and et al},
abstractNote = {Structural genomics efforts have produced structural information, either directly or by modeling, for thousands of proteins over the past few years. While many of these proteins have known functions, a large percentage of them have not been characterized at the functional level. The structural information has provided valuable functional insights on some of these proteins, through careful structural analyses, serendipity, and structure-guided functional screening. Some of the success stories based on structures solved at the Northeast Structural Genomics Consortium (NESG) are reported here. These include a novel methyl salicylate esterase with important role in plant innate immunity, a novel RNA methyltransferase (H. influenzae yggJ (HI0303)), a novel spermidine/spermine N-acetyltransferase (B. subtilis PaiA), a novel methyltransferase or AdoMet binding protein (A. fulgidus AF{_}0241), an ATP:cob(I)alamin adenosyltransferase (B. subtilis YvqK), a novel carboxysome pore (E. coli EutN), a proline racemase homolog with a disrupted active site (B. melitensis BME11586), an FMN-dependent enzyme (S. pneumoniae SP{_}1951), and a 12-stranded {beta}-barrel with a novel fold (V. parahaemolyticus VPA1032).},
doi = {10.1007/s10969-007-9018-3},
journal = {Journal of Structural and Functional Genomics},
number = ,
volume = 8,
place = {United States},
year = {2007},
month = {1}
}