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Title: Atomic Structure of a Short alpha-Helix Stabilized by a Main Chain Hydrogen-Bond Surrogate

Abstract

Herein we report the 1.15 Angstroms X-ray crystal structure of a short {alpha}-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived a-helix truly resembles the structure of canonical a-helices and provides unequivocal support for our helix nucleation strategy.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL) National Synchrotron Light Source
Sponsoring Org.:
Doe - Office Of Science
OSTI Identifier:
959773
Report Number(s):
BNL-82759-2009-JA
Journal ID: ISSN 0002-7863; JACSAT; TRN: US201016%%917
DOE Contract Number:
DE-AC02-98CH10886
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of the American Chemical Society; Journal Volume: 130
Country of Publication:
United States
Language:
English
Subject:
08 HYDROGEN; 36 MATERIALS SCIENCE; CHAINS; CRYSTAL STRUCTURE; HYDROGEN; NUCLEATION; national synchrotron light source

Citation Formats

Liu,J., Wang, D., Zheng, Q., Lu, M., and Arora, P.. Atomic Structure of a Short alpha-Helix Stabilized by a Main Chain Hydrogen-Bond Surrogate. United States: N. p., 2007. Web.
Liu,J., Wang, D., Zheng, Q., Lu, M., & Arora, P.. Atomic Structure of a Short alpha-Helix Stabilized by a Main Chain Hydrogen-Bond Surrogate. United States.
Liu,J., Wang, D., Zheng, Q., Lu, M., and Arora, P.. Mon . "Atomic Structure of a Short alpha-Helix Stabilized by a Main Chain Hydrogen-Bond Surrogate". United States. doi:.
@article{osti_959773,
title = {Atomic Structure of a Short alpha-Helix Stabilized by a Main Chain Hydrogen-Bond Surrogate},
author = {Liu,J. and Wang, D. and Zheng, Q. and Lu, M. and Arora, P.},
abstractNote = {Herein we report the 1.15 Angstroms X-ray crystal structure of a short {alpha}-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived a-helix truly resembles the structure of canonical a-helices and provides unequivocal support for our helix nucleation strategy.},
doi = {},
journal = {Journal of the American Chemical Society},
number = ,
volume = 130,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}
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