Structure and Function of Phosphatidylcholine transfer protein (PC-TP)/StarD2

Journal Article · Mon Jan 01 00:00:00 EST 2007 · Biochimica et Biophysica Acta

DOI:https://doi.org/10.1016/j.bbalip.2007.04.003· OSTI ID:959466

Kanno, K; Wu, M; Scapa, E; Roderick, S; Cohen, D

Phosphatidylcholine transfer protein (PC-TP) is a highly specific soluble lipid binding protein that transfers phosphatidylcholine between membranes in vitro. PC-TP is a member of the steroidogenic acute regulatory protein-related transfer (START) domain superfamily. Although its biochemical properties and structure are well characterized, the functions of PC-TP in vivo remain incompletely understood. Studies of mice with homozygous disruption of the Pctp gene have largely refuted the hypotheses that this protein participates in the hepatocellular selection and transport of biliary phospholipids, in the production of lung surfactant, in leukotriene biosynthesis and in cellular phosphatidylcholine metabolism. Nevertheless, Pctp-/- mice exhibit interesting defects in lipid homeostasis, the understanding of which should elucidate the biological functions of PC-TP.

• Research Organization: Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source
• Sponsoring Organization: Doe - Office Of Science
• DOE Contract Number: DE-AC02-98CH10886
• OSTI ID: 959466
• Report Number(s): BNL-82452-2009-JA; BBACAQ; TRN: US201016%%610
• Journal Information: Biochimica et Biophysica Acta, Vol. 1771, Issue 6; ISSN 0006-3002
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
BIOLOGICAL FUNCTIONS
BIOSYNTHESIS
DEFECTS
GENES
HOMEOSTASIS
IN VITRO
IN VIVO
LECITHINS
LIPIDS
LUNGS
MEMBRANES
METABOLISM
MICE
PHOSPHOLIPIDS
PRODUCTION
PROTEINS
TRANSPORT
national synchrotron light source