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Title: Structure and Function of Phosphatidylcholine transfer protein (PC-TP)/StarD2

Abstract

Phosphatidylcholine transfer protein (PC-TP) is a highly specific soluble lipid binding protein that transfers phosphatidylcholine between membranes in vitro. PC-TP is a member of the steroidogenic acute regulatory protein-related transfer (START) domain superfamily. Although its biochemical properties and structure are well characterized, the functions of PC-TP in vivo remain incompletely understood. Studies of mice with homozygous disruption of the Pctp gene have largely refuted the hypotheses that this protein participates in the hepatocellular selection and transport of biliary phospholipids, in the production of lung surfactant, in leukotriene biosynthesis and in cellular phosphatidylcholine metabolism. Nevertheless, Pctp-/- mice exhibit interesting defects in lipid homeostasis, the understanding of which should elucidate the biological functions of PC-TP.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL) National Synchrotron Light Source
Sponsoring Org.:
Doe - Office Of Science
OSTI Identifier:
959466
Report Number(s):
BNL-82452-2009-JA
Journal ID: ISSN 0006-3002; BBACAQ; TRN: US201016%%610
DOE Contract Number:
DE-AC02-98CH10886
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochimica et Biophysica Acta; Journal Volume: 1771; Journal Issue: 6
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; BIOLOGICAL FUNCTIONS; BIOSYNTHESIS; DEFECTS; GENES; HOMEOSTASIS; IN VITRO; IN VIVO; LECITHINS; LIPIDS; LUNGS; MEMBRANES; METABOLISM; MICE; PHOSPHOLIPIDS; PRODUCTION; PROTEINS; TRANSPORT; national synchrotron light source

Citation Formats

Kanno,K., Wu, M., Scapa, E., Roderick, S., and Cohen, D. Structure and Function of Phosphatidylcholine transfer protein (PC-TP)/StarD2. United States: N. p., 2007. Web. doi:10.1016/j.bbalip.2007.04.003.
Kanno,K., Wu, M., Scapa, E., Roderick, S., & Cohen, D. Structure and Function of Phosphatidylcholine transfer protein (PC-TP)/StarD2. United States. doi:10.1016/j.bbalip.2007.04.003.
Kanno,K., Wu, M., Scapa, E., Roderick, S., and Cohen, D. Mon . "Structure and Function of Phosphatidylcholine transfer protein (PC-TP)/StarD2". United States. doi:10.1016/j.bbalip.2007.04.003.
@article{osti_959466,
title = {Structure and Function of Phosphatidylcholine transfer protein (PC-TP)/StarD2},
author = {Kanno,K. and Wu, M. and Scapa, E. and Roderick, S. and Cohen, D.},
abstractNote = {Phosphatidylcholine transfer protein (PC-TP) is a highly specific soluble lipid binding protein that transfers phosphatidylcholine between membranes in vitro. PC-TP is a member of the steroidogenic acute regulatory protein-related transfer (START) domain superfamily. Although its biochemical properties and structure are well characterized, the functions of PC-TP in vivo remain incompletely understood. Studies of mice with homozygous disruption of the Pctp gene have largely refuted the hypotheses that this protein participates in the hepatocellular selection and transport of biliary phospholipids, in the production of lung surfactant, in leukotriene biosynthesis and in cellular phosphatidylcholine metabolism. Nevertheless, Pctp-/- mice exhibit interesting defects in lipid homeostasis, the understanding of which should elucidate the biological functions of PC-TP.},
doi = {10.1016/j.bbalip.2007.04.003},
journal = {Biochimica et Biophysica Acta},
number = 6,
volume = 1771,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}