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Title: The Effect of Polymer Composition on the Gelation Behavior of PLGA-g-PEG Biodegradable Thermoreversible Gels

Abstract

Graft copolymers consisting of a poly(DL-lactic acid–co–glycolic acid) backbone grafted with polyethyelene glycol (PLGA-g-PEG) side chains were synthesized and formed thermoreversible gels in aqueous solutions which exhibited solution behavior at low temperature and sol-gel transitions at higher temperature. The composition of the polymer and relative amounts of polylactic acid (LA), glycolic acid (GA), and ethylene glycol (EG) could be varied by controlling the precursor concentrations and reaction temperature. The gelation temperature could be systematically tailored from 15°C to 34°C by increasing the concentration of PEG in the graft copolymer. The gelation temperature decreased with increasing polymer molecular weight and decreasing polymer concentration. This work has importance for the development of water soluble gels with tailored compositions and gelation temperatures for use in tissue engineering and as injectable depots for drug delivery.

Authors:
; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
958472
Report Number(s):
PNNL-SA-59333
TRN: US201002%%48
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Journal of Biomedical Materials Research. Part A, 89A(1):248-254
Additional Journal Information:
Journal Volume: 89A; Journal Issue: 1
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; AQUEOUS SOLUTIONS; COPOLYMERS; GELATION; GLYCOLIC ACID; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; SYNTHESIS; CHEMICAL COMPOSITION; CHEMICAL REACTION KINETICS; thermoreversible gels, drug delivery, polymers, tissue engineering

Citation Formats

Tarasevich, Barbara J, Gutowska, Anna, Li, Xiaohong S, and Jeong, Byeongmoon. The Effect of Polymer Composition on the Gelation Behavior of PLGA-g-PEG Biodegradable Thermoreversible Gels. United States: N. p., 2009. Web. doi:10.1002/jbm.a.32025.
Tarasevich, Barbara J, Gutowska, Anna, Li, Xiaohong S, & Jeong, Byeongmoon. The Effect of Polymer Composition on the Gelation Behavior of PLGA-g-PEG Biodegradable Thermoreversible Gels. United States. doi:10.1002/jbm.a.32025.
Tarasevich, Barbara J, Gutowska, Anna, Li, Xiaohong S, and Jeong, Byeongmoon. Wed . "The Effect of Polymer Composition on the Gelation Behavior of PLGA-g-PEG Biodegradable Thermoreversible Gels". United States. doi:10.1002/jbm.a.32025.
@article{osti_958472,
title = {The Effect of Polymer Composition on the Gelation Behavior of PLGA-g-PEG Biodegradable Thermoreversible Gels},
author = {Tarasevich, Barbara J and Gutowska, Anna and Li, Xiaohong S and Jeong, Byeongmoon},
abstractNote = {Graft copolymers consisting of a poly(DL-lactic acid–co–glycolic acid) backbone grafted with polyethyelene glycol (PLGA-g-PEG) side chains were synthesized and formed thermoreversible gels in aqueous solutions which exhibited solution behavior at low temperature and sol-gel transitions at higher temperature. The composition of the polymer and relative amounts of polylactic acid (LA), glycolic acid (GA), and ethylene glycol (EG) could be varied by controlling the precursor concentrations and reaction temperature. The gelation temperature could be systematically tailored from 15°C to 34°C by increasing the concentration of PEG in the graft copolymer. The gelation temperature decreased with increasing polymer molecular weight and decreasing polymer concentration. This work has importance for the development of water soluble gels with tailored compositions and gelation temperatures for use in tissue engineering and as injectable depots for drug delivery.},
doi = {10.1002/jbm.a.32025},
journal = {Journal of Biomedical Materials Research. Part A, 89A(1):248-254},
number = 1,
volume = 89A,
place = {United States},
year = {2009},
month = {4}
}