Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus
- Richland, WA
- Fall City, WA
- Pasco, WA
The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to another molecule comprising a coding region of a gene of interest. The gene regulatory element and gene transcription terminator may temporally and spatially regulate expression of particular genes for optimum production of compounds of interest in a transgenic fungus.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- DE-AC06-76RL01830
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Number(s):
- 7,449,569
- Application Number:
- 10/920,625
- OSTI ID:
- 956997
- Country of Publication:
- United States
- Language:
- English
Identification of an essential upstream element in the nopaline synthase promoter by stable and transient assays
|
journal | August 1987 |
GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants.
|
journal | December 1987 |
Expression of the Escherichia coli β-glucuronidase gene in industrial and phytopathogenic filamentous fungi
|
journal | March 1989 |
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