Compositions and Methods for the Treatment of Pierce's Disease

Gupta, Goutam

Compositions and Methods for the Treatment of Pierce's Disease

Patent · 07 October 2008

OSTI ID:953732

Gupta, Goutam ^[1]

Santa Fe, NM

Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenic Vitus vinefera plants expressing xylem-secreted anti-microbial chimeras are also provided.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM

Sponsoring Organization:: United States Department of Energy

Assignee:: Los Alamos National Security, LLC (Los Alamos, NM)

Patent Number(s):: 7,432,419

Application Number:: 10/846,172

OSTI ID:: 953732

Country of Publication:: United States

Language:: English

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