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Title: A Comparison of Rapid-Scanning X-Ray Fluorescence Mapping And Magnetic Resonance Imaging to Localize Brain Iron Distribution

Abstract

The clinical diagnosis of many neurodegenerative disorders relies primarily or exclusively on observed behaviors rather than measurable physical tests. One of the hallmarks of Alzheimer disease (AD) is the presence of amyloid-containing plaques associated with deposits of iron, copper and/or zinc. Work in other laboratories has shown that iron-rich plaques can be seen in the mouse brain in vivo with magnetic resonance imaging (MRI) using a high-field strength magnet but this iron cannot be visualized in humans using clinical magnets. To improve the interpretation of MRI, we correlated iron accumulation visualized by X-ray fluorescence spectroscopy, an element-specific technique with T1, T2, and susceptibility weighted MR (SWI) in a mouse model of AD. We show that SWI best shows areas of increased iron accumulation when compared to standard sequences.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Stanford Linear Accelerator Center (SLAC)
Sponsoring Org.:
USDOE
OSTI Identifier:
953613
Report Number(s):
SLAC-REPRINT-2009-270
Journal ID: ISSN 0720-048X; EJRADR; TRN: US201002%%1441
DOE Contract Number:  
AC02-76SF00515
Resource Type:
Journal Article
Journal Name:
Eur. J. Radiol. 68:109,2008
Additional Journal Information:
Journal Volume: 68; Journal Issue: 3Sup1; Journal ID: ISSN 0720-048X
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; BEHAVIOR; BUILDUP; COPPER; DEPOSITS; DIAGNOSIS; DISEASES; DISTRIBUTION; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; HUMAN POPULATIONS; IN VIVO; IRON; LABORATORIES; MAGNETIC RESONANCE; MAGNETS; MAPPING; STANDARDS; ZINC; Other,OTHER

Citation Formats

McCrea, R P.E., Harder, S L, Martin, M, Buist, R, and Nichol, H. A Comparison of Rapid-Scanning X-Ray Fluorescence Mapping And Magnetic Resonance Imaging to Localize Brain Iron Distribution. United States: N. p., 2009. Web.
McCrea, R P.E., Harder, S L, Martin, M, Buist, R, & Nichol, H. A Comparison of Rapid-Scanning X-Ray Fluorescence Mapping And Magnetic Resonance Imaging to Localize Brain Iron Distribution. United States.
McCrea, R P.E., Harder, S L, Martin, M, Buist, R, and Nichol, H. Tue . "A Comparison of Rapid-Scanning X-Ray Fluorescence Mapping And Magnetic Resonance Imaging to Localize Brain Iron Distribution". United States.
@article{osti_953613,
title = {A Comparison of Rapid-Scanning X-Ray Fluorescence Mapping And Magnetic Resonance Imaging to Localize Brain Iron Distribution},
author = {McCrea, R P.E. and Harder, S L and Martin, M and Buist, R and Nichol, H},
abstractNote = {The clinical diagnosis of many neurodegenerative disorders relies primarily or exclusively on observed behaviors rather than measurable physical tests. One of the hallmarks of Alzheimer disease (AD) is the presence of amyloid-containing plaques associated with deposits of iron, copper and/or zinc. Work in other laboratories has shown that iron-rich plaques can be seen in the mouse brain in vivo with magnetic resonance imaging (MRI) using a high-field strength magnet but this iron cannot be visualized in humans using clinical magnets. To improve the interpretation of MRI, we correlated iron accumulation visualized by X-ray fluorescence spectroscopy, an element-specific technique with T1, T2, and susceptibility weighted MR (SWI) in a mouse model of AD. We show that SWI best shows areas of increased iron accumulation when compared to standard sequences.},
doi = {},
url = {https://www.osti.gov/biblio/953613}, journal = {Eur. J. Radiol. 68:109,2008},
issn = {0720-048X},
number = 3Sup1,
volume = 68,
place = {United States},
year = {2009},
month = {5}
}