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Title: Benzo-homologated nucleobases in a nanotube-electrodes setup for DNA sequencing

Abstract

Motivated by the possibility that the conductivity signatures of benzo-homologated DNA bases could be used to sequence DNA, we have investigated the conductivity properties of these bases when they are non-covalently sandwiched between two (5,5) nanotube electrodes. It is found that these bases conduct poorly, making it very difficult to distinguish them. An analysis of the changes in the conductivity of benzo-adenine as a function of the distance between the tips of the nanotubes revealed that, even though the conductance increases by four orders of magnitude when the electrodes are brought closer together, the net conductance remains rather small. These results suggest that benzo-homologated bases, despite having smaller HOMO-LUMO gaps than their natural counterparts, when non-covalently bound to the electrodes cannot be used to sequence DNA by means of conductivity measurements.

Authors:
 [1];  [1];  [1]
  1. ORNL
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Center for Nanophase Materials Sciences
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
950796
DOE Contract Number:  
DE-AC05-00OR22725
Resource Type:
Journal Article
Resource Relation:
Journal Name: Nanotechnology; Journal Volume: 18; Journal Issue: 42
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DNA; DNA SEQUENCING; ELECTRODES; NANOTUBES

Citation Formats

Fuentes-Cabrera, Miguel A, Meunier, Vincent, and Sumpter, Bobby G. Benzo-homologated nucleobases in a nanotube-electrodes setup for DNA sequencing. United States: N. p., 2007. Web. doi:10.1088/0957-4484/18/42/424019.
Fuentes-Cabrera, Miguel A, Meunier, Vincent, & Sumpter, Bobby G. Benzo-homologated nucleobases in a nanotube-electrodes setup for DNA sequencing. United States. doi:10.1088/0957-4484/18/42/424019.
Fuentes-Cabrera, Miguel A, Meunier, Vincent, and Sumpter, Bobby G. Mon . "Benzo-homologated nucleobases in a nanotube-electrodes setup for DNA sequencing". United States. doi:10.1088/0957-4484/18/42/424019.
@article{osti_950796,
title = {Benzo-homologated nucleobases in a nanotube-electrodes setup for DNA sequencing},
author = {Fuentes-Cabrera, Miguel A and Meunier, Vincent and Sumpter, Bobby G},
abstractNote = {Motivated by the possibility that the conductivity signatures of benzo-homologated DNA bases could be used to sequence DNA, we have investigated the conductivity properties of these bases when they are non-covalently sandwiched between two (5,5) nanotube electrodes. It is found that these bases conduct poorly, making it very difficult to distinguish them. An analysis of the changes in the conductivity of benzo-adenine as a function of the distance between the tips of the nanotubes revealed that, even though the conductance increases by four orders of magnitude when the electrodes are brought closer together, the net conductance remains rather small. These results suggest that benzo-homologated bases, despite having smaller HOMO-LUMO gaps than their natural counterparts, when non-covalently bound to the electrodes cannot be used to sequence DNA by means of conductivity measurements.},
doi = {10.1088/0957-4484/18/42/424019},
journal = {Nanotechnology},
number = 42,
volume = 18,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}