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Title: Minimum Detectable Dose as a Measure of Bioassay Programme Capability

Abstract

This paper suggests that minimum detectable dose (MDD) be used to describe the capability of bioassay programs for which intakes are expected to be rare. This allows expression of the capability in units that correspond directly to primary dose limits. The concept uses the well-established analytical statistic minimum detectable amount (MDA) as the starting point and assumes MDA detection at a prescribed time post intake. The resulting dose can then be used as an indication of the adequacy or capability of the program for demonstrating compliance with the performance criteria. MDDs can be readily tabulated or plotted to demonstrate the effectiveness of different types of monitoring programs. The inclusion of cost factors for bioassay measurements can allow optimisation.

Authors:
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
945240
Report Number(s):
PNNL-SA-37060
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Radiation Protection Dosimetry, 105(No. 1-4):391-394
Country of Publication:
United States
Language:
English
Subject:
Biossay; dosimetry; internal dosimetry

Citation Formats

Carbaugh, Eugene H. Minimum Detectable Dose as a Measure of Bioassay Programme Capability. United States: N. p., 2003. Web. doi:10.1093/oxfordjournals.rpd.a006266.
Carbaugh, Eugene H. Minimum Detectable Dose as a Measure of Bioassay Programme Capability. United States. doi:10.1093/oxfordjournals.rpd.a006266.
Carbaugh, Eugene H. Wed . "Minimum Detectable Dose as a Measure of Bioassay Programme Capability". United States. doi:10.1093/oxfordjournals.rpd.a006266.
@article{osti_945240,
title = {Minimum Detectable Dose as a Measure of Bioassay Programme Capability},
author = {Carbaugh, Eugene H.},
abstractNote = {This paper suggests that minimum detectable dose (MDD) be used to describe the capability of bioassay programs for which intakes are expected to be rare. This allows expression of the capability in units that correspond directly to primary dose limits. The concept uses the well-established analytical statistic minimum detectable amount (MDA) as the starting point and assumes MDA detection at a prescribed time post intake. The resulting dose can then be used as an indication of the adequacy or capability of the program for demonstrating compliance with the performance criteria. MDDs can be readily tabulated or plotted to demonstrate the effectiveness of different types of monitoring programs. The inclusion of cost factors for bioassay measurements can allow optimisation.},
doi = {10.1093/oxfordjournals.rpd.a006266},
journal = {Radiation Protection Dosimetry, 105(No. 1-4):391-394},
number = ,
volume = ,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 2003},
month = {Wed Jan 01 00:00:00 EST 2003}
}