skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Microfabricated Instrumentation for Chemical Sensing in Industrial Process Control

Abstract

The monitoring of chemical constituents in manufacturing processes is of economic importance to most industries. The monitoring and control of chemical constituents may be of importance for product quality control or, in the case of process effluents, of environmental concern. The most common approach now employed for chemical process control is to collect samples which are returned to a conventional chemical analysis laboratory. This project attempts to demonstrate the use of microfabricated structures, referred to as 'lab-on-a-chip' devices, that accomplish chemical measurement tasks that emulate those performed in the conventional laboratory. The devices envisioned could be used as hand portable chemical analysis instruments where samples are analyzed in the field or as emplaced sensors for continuous 'real-time' monitoring. This project focuses on the development of filtration elements and solid phase extraction elements that can be monolithically integrated onto electrophoresis and chromatographic structures pioneered in the laboratory. Successful demonstration of these additional functional elements on integrated microfabricated devices allows lab-on-a-chip technologies to address real world samples that would be encountered in process control environments. The resultant technology has a broad application to industrial environmental monitoring problems. such as monitoring municipal water supplies, waste water effluent from industrial facilities, or monitoring ofmore » run-off from agricultural activities. The technology will also be adaptable to manufacturing process control scenarios. Microfabricated devices integrating sample filtration, solid phase extraction, and chromatographic separation with solvent programming were demonstrated. Filtering of the sample was accomplished at the same inlet with an array of seven channels each 1 {micro}m deep and 18 {micro}m wide. Sample concentration and separation were performed on channels 5 {micro}m deep and 25 {micro}m wide coated with a C18 phase, and elution was achieved under isocratic, step, or linear gradient conditions. For the solid phase extraction signal enhancement factors of 400 over a standard injection of 1.0 s were observed for a 320 s injection. Four polycyclic aromatic compounds (PAHs) were resolved by open channel electrochromatography in under 50 s. Chip operation was unaffected by the presence of the 5 {micro}m silica particles at the filter entrance.« less

Authors:
Publication Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
940379
Report Number(s):
ORNL97-0473
TRN: US200824%%266
DOE Contract Number:  
DE-AC05-00OR22725
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; AROMATICS; CHEMICAL ANALYSIS; ECONOMICS; ELECTROPHORESIS; FILTRATION; FUNCTIONALS; MANUFACTURING; MONITORING; PROCESS CONTROL; PROGRAMMING; QUALITY CONTROL; SILICA; SOLVENTS; WASTE WATER; WATER

Citation Formats

Ramsey, J. M. Microfabricated Instrumentation for Chemical Sensing in Industrial Process Control. United States: N. p., 2000. Web. doi:10.2172/940379.
Ramsey, J. M. Microfabricated Instrumentation for Chemical Sensing in Industrial Process Control. United States. doi:10.2172/940379.
Ramsey, J. M. Thu . "Microfabricated Instrumentation for Chemical Sensing in Industrial Process Control". United States. doi:10.2172/940379. https://www.osti.gov/servlets/purl/940379.
@article{osti_940379,
title = {Microfabricated Instrumentation for Chemical Sensing in Industrial Process Control},
author = {Ramsey, J. M.},
abstractNote = {The monitoring of chemical constituents in manufacturing processes is of economic importance to most industries. The monitoring and control of chemical constituents may be of importance for product quality control or, in the case of process effluents, of environmental concern. The most common approach now employed for chemical process control is to collect samples which are returned to a conventional chemical analysis laboratory. This project attempts to demonstrate the use of microfabricated structures, referred to as 'lab-on-a-chip' devices, that accomplish chemical measurement tasks that emulate those performed in the conventional laboratory. The devices envisioned could be used as hand portable chemical analysis instruments where samples are analyzed in the field or as emplaced sensors for continuous 'real-time' monitoring. This project focuses on the development of filtration elements and solid phase extraction elements that can be monolithically integrated onto electrophoresis and chromatographic structures pioneered in the laboratory. Successful demonstration of these additional functional elements on integrated microfabricated devices allows lab-on-a-chip technologies to address real world samples that would be encountered in process control environments. The resultant technology has a broad application to industrial environmental monitoring problems. such as monitoring municipal water supplies, waste water effluent from industrial facilities, or monitoring of run-off from agricultural activities. The technology will also be adaptable to manufacturing process control scenarios. Microfabricated devices integrating sample filtration, solid phase extraction, and chromatographic separation with solvent programming were demonstrated. Filtering of the sample was accomplished at the same inlet with an array of seven channels each 1 {micro}m deep and 18 {micro}m wide. Sample concentration and separation were performed on channels 5 {micro}m deep and 25 {micro}m wide coated with a C18 phase, and elution was achieved under isocratic, step, or linear gradient conditions. For the solid phase extraction signal enhancement factors of 400 over a standard injection of 1.0 s were observed for a 320 s injection. Four polycyclic aromatic compounds (PAHs) were resolved by open channel electrochromatography in under 50 s. Chip operation was unaffected by the presence of the 5 {micro}m silica particles at the filter entrance.},
doi = {10.2172/940379},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {6}
}