Crystal and molecular structure of a DNA fragment containing a 2-aminoadenine modification : the relationship between conformation, packing, and hydration in Z-DNA hexamers.
The crystal and molecular structure of d(CGUA{prime}CG){sub 2} (where A{prime} is 2-aminoadenine) has been determined and refined to an R factor of 13.8% for data 8.0-1.3 angstroms. The structure is very similar to the original Z-DNA structures with the sequence d(CGCGCG){sub 2} and shows that the substitution of 2-aminoadenine-uracil base pairs in the two central steps is consistent with Z-DNA formation. In addition, we show how waters mediating intermolecular interactions may help to explain the ZI-ZII conformational pattern found in many Z-DNA structures.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- OSTI ID:
- 937875
- Report Number(s):
- ANL/CMB/JA-22598; BICHAW; TRN: US200905%%682
- Journal Information:
- Biochemistry, Vol. 31, Issue 40 ; 1992; ISSN 0006-2960
- Country of Publication:
- United States
- Language:
- ENGLISH
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