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Title: The Trichoplax Genome and the Nature of Placozoans

Abstract

Placozoans are arguably the simplest free-living animals, possibly evoking an early stage in metazoan evolution, yet their biology is poorly understood. Here we report the sequencing and analysis of the {approx}98 million base pair nuclear genome of the placozoan Trichoplax adhaerens. Whole genome phylogenetic analysis suggests that placozoans belong to a 'eumetazoan' clade that includes cnidarians and bilaterians, with sponges as the earliest diverging animals. The compact genome exhibits conserved gene content, gene structure, and synteny relative to the human and other complex eumetazoan genomes. Despite the apparent cellular and organismal simplicity of Trichoplax, its genome encodes a rich array of transcription factor and signaling pathway genes that are typically associated with diverse cell types and developmental processes in eumetazoans, motivating further searches for cryptic cellular complexity and/or as yet unobserved life history stages.

Authors:
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Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
Genomics Division
OSTI Identifier:
937506
Report Number(s):
LBNL-967E
TRN: US200819%%233
DOE Contract Number:  
DE-AC02-05CH11231
Resource Type:
Journal Article
Journal Name:
Nature
Additional Journal Information:
Related Information: Journal Publication Date: 2007
Country of Publication:
United States
Language:
English
Subject:
59; ANIMALS; BIOLOGY; GENES; TRANSCRIPTION FACTORS

Citation Formats

Srivastava, Mansi, Begovic, Emina, Chapman, Jarrod, Putnam, Nicholas H, Hellsten, Uffe, Kawashima, Takeshi, Kuo, Alan, Mitros, Therese, Salamov, Asaf, Carpenter, Meredith L, Signorovitch, Ana Y, Moreno, Maria A, Kamm, Kai, Grimwood, Jane, Schmutz, Jeremy, Shapiro, Harris, Grigoriev, Igor V, Buss, Leo W, Schierwater, Bernd, Dellaporta, Stephen L, and Rokhsar, Daniel S. The Trichoplax Genome and the Nature of Placozoans. United States: N. p., 2008. Web. doi:10.1038/nature07191.
Srivastava, Mansi, Begovic, Emina, Chapman, Jarrod, Putnam, Nicholas H, Hellsten, Uffe, Kawashima, Takeshi, Kuo, Alan, Mitros, Therese, Salamov, Asaf, Carpenter, Meredith L, Signorovitch, Ana Y, Moreno, Maria A, Kamm, Kai, Grimwood, Jane, Schmutz, Jeremy, Shapiro, Harris, Grigoriev, Igor V, Buss, Leo W, Schierwater, Bernd, Dellaporta, Stephen L, & Rokhsar, Daniel S. The Trichoplax Genome and the Nature of Placozoans. United States. https://doi.org/10.1038/nature07191
Srivastava, Mansi, Begovic, Emina, Chapman, Jarrod, Putnam, Nicholas H, Hellsten, Uffe, Kawashima, Takeshi, Kuo, Alan, Mitros, Therese, Salamov, Asaf, Carpenter, Meredith L, Signorovitch, Ana Y, Moreno, Maria A, Kamm, Kai, Grimwood, Jane, Schmutz, Jeremy, Shapiro, Harris, Grigoriev, Igor V, Buss, Leo W, Schierwater, Bernd, Dellaporta, Stephen L, and Rokhsar, Daniel S. 2008. "The Trichoplax Genome and the Nature of Placozoans". United States. https://doi.org/10.1038/nature07191. https://www.osti.gov/servlets/purl/937506.
@article{osti_937506,
title = {The Trichoplax Genome and the Nature of Placozoans},
author = {Srivastava, Mansi and Begovic, Emina and Chapman, Jarrod and Putnam, Nicholas H and Hellsten, Uffe and Kawashima, Takeshi and Kuo, Alan and Mitros, Therese and Salamov, Asaf and Carpenter, Meredith L and Signorovitch, Ana Y and Moreno, Maria A and Kamm, Kai and Grimwood, Jane and Schmutz, Jeremy and Shapiro, Harris and Grigoriev, Igor V and Buss, Leo W and Schierwater, Bernd and Dellaporta, Stephen L and Rokhsar, Daniel S},
abstractNote = {Placozoans are arguably the simplest free-living animals, possibly evoking an early stage in metazoan evolution, yet their biology is poorly understood. Here we report the sequencing and analysis of the {approx}98 million base pair nuclear genome of the placozoan Trichoplax adhaerens. Whole genome phylogenetic analysis suggests that placozoans belong to a 'eumetazoan' clade that includes cnidarians and bilaterians, with sponges as the earliest diverging animals. The compact genome exhibits conserved gene content, gene structure, and synteny relative to the human and other complex eumetazoan genomes. Despite the apparent cellular and organismal simplicity of Trichoplax, its genome encodes a rich array of transcription factor and signaling pathway genes that are typically associated with diverse cell types and developmental processes in eumetazoans, motivating further searches for cryptic cellular complexity and/or as yet unobserved life history stages.},
doi = {10.1038/nature07191},
url = {https://www.osti.gov/biblio/937506}, journal = {Nature},
number = ,
volume = ,
place = {United States},
year = {Fri Aug 01 00:00:00 EDT 2008},
month = {Fri Aug 01 00:00:00 EDT 2008}
}