Automated High Throughput Drug Target Crystallography
The molecular structures of drug target proteins and receptors form the basis for 'rational' or structure guided drug design. The majority of target structures are experimentally determined by protein X-ray crystallography, which as evolved into a highly automated, high throughput drug discovery and screening tool. Process automation has accelerated tasks from parallel protein expression, fully automated crystallization, and rapid data collection to highly efficient structure determination methods. A thoroughly designed automation technology platform supported by a powerful informatics infrastructure forms the basis for optimal workflow implementation and the data mining and analysis tools to generate new leads from experimental protein drug target structures.
- Research Organization:
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 936949
- Report Number(s):
- UCRL-JRNL-209860; TRN: US200821%%150
- Journal Information:
- American Pharmaceutical Review, N/A, no. 9/10, September 1, 2005, pp. 14, Journal Issue: 9/10
- Country of Publication:
- United States
- Language:
- English
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