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Title: Response Funtions for Computing Absorbed Dose to Skeletal Tissues from Photon Irradiation

Abstract

The calculation of absorbed dose in skeletal tissues at radiogenic risk has been a difficult problem because the relevant structures cannot be represented in conventional geometric terms nor can they be visualised in the tomographic image data used to define the computational models of the human body. The active marrow, the tissue of concern in leukaemia induction, is present within the spongiosa regions of trabecular bone, whereas the osteoprogenitor cells at risk for bone cancer induction are considered to be within the soft tissues adjacent to the mineral surfaces. The International Commission on Radiological Protection (ICRP) recommends averaging the absorbed energy over the active marrow within the spongiosa and over the soft tissues within 10 mm of the mineral surface for leukaemia and bone cancer induction, respectively. In its forthcoming recommendation, it is expected that the latter guidance will be changed to include soft tissues within 50 mm of the mineral surfaces. To address the computational problems, the skeleton of the proposed ICRP reference computational phantom has been subdivided to identify those voxels associated with cortical shell, spongiosa and the medullary cavity of the long bones. It is further proposed that the Monte Carlo calculations with these phantoms compute themore » energy deposition in the skeletal target tissues as the product of the particle fluence in the skeletal subdivisions and applicable fluence-to-dose response functions. This paper outlines the development of such response functions for photons.« less

Authors:
 [1];  [2];  [3];  [3]
  1. ORNL
  2. University of Florida, Gainesville
  3. Institute of Radiation Protection, GSF-National Reserach Center for Environ
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
ORNL other overhead
OSTI Identifier:
934948
DOE Contract Number:  
DE-AC05-00OR22725
Resource Type:
Journal Article
Resource Relation:
Journal Name: Radiation Protection Dosimetry; Journal Volume: 127; Journal Issue: 1-4
Country of Publication:
United States
Language:
English
Subject:
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS; INDUCTION; IRRADIATION; LEUKEMIA; NEOPLASMS; PHANTOMS; PHOTONS; RADIATION DOSES; RADIATION PROTECTION; RESPONSE FUNCTIONS; SKELETON; TARGETS; TRABECULAR BONE

Citation Formats

Eckerman, Keith F, Bolch, W E, Zankl, M, and Petoussi-Henss, N. Response Funtions for Computing Absorbed Dose to Skeletal Tissues from Photon Irradiation. United States: N. p., 2007. Web. doi:10.1093/rpd/ncm468.
Eckerman, Keith F, Bolch, W E, Zankl, M, & Petoussi-Henss, N. Response Funtions for Computing Absorbed Dose to Skeletal Tissues from Photon Irradiation. United States. doi:10.1093/rpd/ncm468.
Eckerman, Keith F, Bolch, W E, Zankl, M, and Petoussi-Henss, N. Mon . "Response Funtions for Computing Absorbed Dose to Skeletal Tissues from Photon Irradiation". United States. doi:10.1093/rpd/ncm468.
@article{osti_934948,
title = {Response Funtions for Computing Absorbed Dose to Skeletal Tissues from Photon Irradiation},
author = {Eckerman, Keith F and Bolch, W E and Zankl, M and Petoussi-Henss, N},
abstractNote = {The calculation of absorbed dose in skeletal tissues at radiogenic risk has been a difficult problem because the relevant structures cannot be represented in conventional geometric terms nor can they be visualised in the tomographic image data used to define the computational models of the human body. The active marrow, the tissue of concern in leukaemia induction, is present within the spongiosa regions of trabecular bone, whereas the osteoprogenitor cells at risk for bone cancer induction are considered to be within the soft tissues adjacent to the mineral surfaces. The International Commission on Radiological Protection (ICRP) recommends averaging the absorbed energy over the active marrow within the spongiosa and over the soft tissues within 10 mm of the mineral surface for leukaemia and bone cancer induction, respectively. In its forthcoming recommendation, it is expected that the latter guidance will be changed to include soft tissues within 50 mm of the mineral surfaces. To address the computational problems, the skeleton of the proposed ICRP reference computational phantom has been subdivided to identify those voxels associated with cortical shell, spongiosa and the medullary cavity of the long bones. It is further proposed that the Monte Carlo calculations with these phantoms compute the energy deposition in the skeletal target tissues as the product of the particle fluence in the skeletal subdivisions and applicable fluence-to-dose response functions. This paper outlines the development of such response functions for photons.},
doi = {10.1093/rpd/ncm468},
journal = {Radiation Protection Dosimetry},
number = 1-4,
volume = 127,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}