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Title: Assessing the pulmonary toxicity of single-walled carbon nanohorns

Abstract

Previous studies have suggested that single-walled carbon nanotubes (SWCNTs) may be pose a pulmonary hazard. We investigated the pulmonary toxicity of single-walled carbon nanohorns (SWCNHs), a relatively new carbon-based nanomaterial that is structurally similar to SWCNTs. Mice were exposed to 30 g of surfactant-suspended SWCNHs by pharyngeal aspiration and sacrificed 24 hours or 7 days post exposure. Total and differential cell counts and cytokine analysis of bronchoalveolar lavage fluid demonstrated a mild inflammatory response which was mitigated by day 7 post exposure. Whole lung microarray analysis demonstrated that SWCNH-exposure did not lead to robust changes in gene expression. Finally, histological analysis showed no evidence of granuloma formation or fibrosis following SWCNH aspiration. These combined results suggest that SWCNH is a relatively innocuous nanomaterial when delivered to mice in vivo using aspiration as a delivery mechanism.

Authors:
 [1];  [1];  [1];  [1];  [2];  [2];  [1]
  1. ORNL
  2. University of Tennessee, Knoxville (UTK)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mouse Genetics Research Facility
Sponsoring Org.:
USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE Office of Science (SC)
OSTI Identifier:
932105
DOE Contract Number:
DE-AC05-00OR22725
Resource Type:
Journal Article
Resource Relation:
Journal Name: Nanotoxicology; Journal Volume: 1; Journal Issue: 2
Country of Publication:
United States
Language:
English
Subject:
Single-walled carbon nanohorns; nanotoxicology; aspiration; inflammatory

Citation Formats

Lynch, Rachel M, Voy, Brynn H, Glass-Mattie, Dana F, Mahurin, Shannon Mark, Saxton, Arnold, Donnel, Robert L., and Cheng, Mengdawn. Assessing the pulmonary toxicity of single-walled carbon nanohorns. United States: N. p., 2007. Web. doi:10.1080/17435390701598496.
Lynch, Rachel M, Voy, Brynn H, Glass-Mattie, Dana F, Mahurin, Shannon Mark, Saxton, Arnold, Donnel, Robert L., & Cheng, Mengdawn. Assessing the pulmonary toxicity of single-walled carbon nanohorns. United States. doi:10.1080/17435390701598496.
Lynch, Rachel M, Voy, Brynn H, Glass-Mattie, Dana F, Mahurin, Shannon Mark, Saxton, Arnold, Donnel, Robert L., and Cheng, Mengdawn. Mon . "Assessing the pulmonary toxicity of single-walled carbon nanohorns". United States. doi:10.1080/17435390701598496.
@article{osti_932105,
title = {Assessing the pulmonary toxicity of single-walled carbon nanohorns},
author = {Lynch, Rachel M and Voy, Brynn H and Glass-Mattie, Dana F and Mahurin, Shannon Mark and Saxton, Arnold and Donnel, Robert L. and Cheng, Mengdawn},
abstractNote = {Previous studies have suggested that single-walled carbon nanotubes (SWCNTs) may be pose a pulmonary hazard. We investigated the pulmonary toxicity of single-walled carbon nanohorns (SWCNHs), a relatively new carbon-based nanomaterial that is structurally similar to SWCNTs. Mice were exposed to 30 g of surfactant-suspended SWCNHs by pharyngeal aspiration and sacrificed 24 hours or 7 days post exposure. Total and differential cell counts and cytokine analysis of bronchoalveolar lavage fluid demonstrated a mild inflammatory response which was mitigated by day 7 post exposure. Whole lung microarray analysis demonstrated that SWCNH-exposure did not lead to robust changes in gene expression. Finally, histological analysis showed no evidence of granuloma formation or fibrosis following SWCNH aspiration. These combined results suggest that SWCNH is a relatively innocuous nanomaterial when delivered to mice in vivo using aspiration as a delivery mechanism.},
doi = {10.1080/17435390701598496},
journal = {Nanotoxicology},
number = 2,
volume = 1,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}