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Title: Techno-economic analysis of biocatalytic processes for production of alkene expoxides

Abstract

A techno-economic analysis of two different bioprocesses was conducted, one for the conversion of propylene to propylene oxide (PO) and other for conversion of styrene to styrene expoxide (SO). The first process was a lipase-mediated chemo-enzymatic reaction, whereas the second one was a one-step enzymatic process using chloroperoxidase. The PO produced through the chemo-enzymatic process is a racemic product, whereas the latter process (based on chloroperoxidase) produces an enantio-pure product. The former process thus falls under the category of high-volume commodity chemical (PO); whereas the latter is a low-volume, high-value product (SO).A simulation of the process was conducted using the bioprocess engineering software SuperPro Designer v6.0 (Intelligen, Inc., Scotch Plains, NJ) to determine the economic feasibility of the process. The purpose of the exercise was to compare biocatalytic processes with existing chemical processes for production of alkene expoxides. The results show that further improvements are needed in improving biocatalyst stability to make these bioprocesses competitive with chemical processes.

Authors:
 [1]
  1. ORNL
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
Work for Others (WFO)
OSTI Identifier:
931939
DOE Contract Number:  
DE-AC05-00OR22725
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Biochemistry and Biotechnology; Journal Volume: 137
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; EPOXIDES; ALKENES; BIOSYNTHESIS; ECONOMICS; PROPYLENE; STYRENE; OXIDATION; COMPUTERIZED SIMULATION; Alkene epoxidation

Citation Formats

Borole, Abhijeet P. Techno-economic analysis of biocatalytic processes for production of alkene expoxides. United States: N. p., 2007. Web. doi:10.1007/s12010-007-9070-2.
Borole, Abhijeet P. Techno-economic analysis of biocatalytic processes for production of alkene expoxides. United States. doi:10.1007/s12010-007-9070-2.
Borole, Abhijeet P. Mon . "Techno-economic analysis of biocatalytic processes for production of alkene expoxides". United States. doi:10.1007/s12010-007-9070-2.
@article{osti_931939,
title = {Techno-economic analysis of biocatalytic processes for production of alkene expoxides},
author = {Borole, Abhijeet P},
abstractNote = {A techno-economic analysis of two different bioprocesses was conducted, one for the conversion of propylene to propylene oxide (PO) and other for conversion of styrene to styrene expoxide (SO). The first process was a lipase-mediated chemo-enzymatic reaction, whereas the second one was a one-step enzymatic process using chloroperoxidase. The PO produced through the chemo-enzymatic process is a racemic product, whereas the latter process (based on chloroperoxidase) produces an enantio-pure product. The former process thus falls under the category of high-volume commodity chemical (PO); whereas the latter is a low-volume, high-value product (SO).A simulation of the process was conducted using the bioprocess engineering software SuperPro Designer v6.0 (Intelligen, Inc., Scotch Plains, NJ) to determine the economic feasibility of the process. The purpose of the exercise was to compare biocatalytic processes with existing chemical processes for production of alkene expoxides. The results show that further improvements are needed in improving biocatalyst stability to make these bioprocesses competitive with chemical processes.},
doi = {10.1007/s12010-007-9070-2},
journal = {Applied Biochemistry and Biotechnology},
number = ,
volume = 137,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}