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Title: Reply to "Comment on 'Characterization of the Tunneling Conductance Across DNA Bases'"

Abstract

Lagerqvist et al.'s Comment regarding the calculation of the transverse conductance of a single-strand DNA heteropolymer translocated through a nanogap between two metal electrodes fully confirms the main conclusions of our study [Phys. Rev. E 74, 011919 (2006)]. In the absence of resonant tunneling, the sensitivity to geometrical factors and the uncertainty in the density functional theory model, which is used in our study and is the basis for the parametrization of the model used by Lagerqvist et al., raises doubt about the utility of static-bias measurements for DNA sequencing. A possible scheme discussed by Lagerqvist et al., the stabilization of geometry by an applied strong transverse voltage (1 V), is outside the applicability range of the near-equilibrium theory they (and we) used. More advanced theories and precise gap measurements are needed to resolve these issues.

Authors:
 [1];  [1];  [1];  [1];  [1];  [1]
  1. ORNL
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
931819
DOE Contract Number:  
DE-AC05-00OR22725
Resource Type:
Journal Article
Resource Relation:
Journal Name: Physical Review E; Journal Volume: 76; Journal Issue: 1
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DNA; DNA SEQUENCING; ELECTRODES; FUNCTIONALS; GEOMETRY; SENSITIVITY; STABILIZATION; TUNNELING

Citation Formats

Zikic, Radomir, Krstic, Predrag S, Zhang, Xiaoguang, Fuentes-Cabrera, Miguel A, Wells, Jack C, and Zhao, Xiongce. Reply to "Comment on 'Characterization of the Tunneling Conductance Across DNA Bases'". United States: N. p., 2007. Web. doi:10.1103/PhysRevE.76.013902.
Zikic, Radomir, Krstic, Predrag S, Zhang, Xiaoguang, Fuentes-Cabrera, Miguel A, Wells, Jack C, & Zhao, Xiongce. Reply to "Comment on 'Characterization of the Tunneling Conductance Across DNA Bases'". United States. doi:10.1103/PhysRevE.76.013902.
Zikic, Radomir, Krstic, Predrag S, Zhang, Xiaoguang, Fuentes-Cabrera, Miguel A, Wells, Jack C, and Zhao, Xiongce. Mon . "Reply to "Comment on 'Characterization of the Tunneling Conductance Across DNA Bases'"". United States. doi:10.1103/PhysRevE.76.013902.
@article{osti_931819,
title = {Reply to "Comment on 'Characterization of the Tunneling Conductance Across DNA Bases'"},
author = {Zikic, Radomir and Krstic, Predrag S and Zhang, Xiaoguang and Fuentes-Cabrera, Miguel A and Wells, Jack C and Zhao, Xiongce},
abstractNote = {Lagerqvist et al.'s Comment regarding the calculation of the transverse conductance of a single-strand DNA heteropolymer translocated through a nanogap between two metal electrodes fully confirms the main conclusions of our study [Phys. Rev. E 74, 011919 (2006)]. In the absence of resonant tunneling, the sensitivity to geometrical factors and the uncertainty in the density functional theory model, which is used in our study and is the basis for the parametrization of the model used by Lagerqvist et al., raises doubt about the utility of static-bias measurements for DNA sequencing. A possible scheme discussed by Lagerqvist et al., the stabilization of geometry by an applied strong transverse voltage (1 V), is outside the applicability range of the near-equilibrium theory they (and we) used. More advanced theories and precise gap measurements are needed to resolve these issues.},
doi = {10.1103/PhysRevE.76.013902},
journal = {Physical Review E},
number = 1,
volume = 76,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}