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Title: Assessing the pulmonary toxicity of single-walled carbon nanohorns

Abstract

Previous studies have suggested that single-walled carbon nanotubes (SWCNTs) may pose a pulmonary hazard. We investigated the pulmonary toxicity of single-walled carbon nanohorns (SWCNHs), a relatively new carbon-based nanomaterial that is structurally similar to SWCNTs. Mice were exposed to 30 {micro}g of surfactant-suspended SWCNHs or an equal volume of vehicle control by pharyngeal aspiration and sacrificed 24 hours or 7 days post-exposure. Total and differential cell counts and cytokine analysis of bronchoalveolar lavage fluid demonstrated a mild inflammatory response which was mitigated by day 7 post-exposure. Whole lung microarray analysis demonstrated that SWCNH-exposure did not lead to robust changes in gene expression. Finally, histological analysis showed no evidence of granuloma formation or fibrosis following SWCNH aspiration. These combined results suggest that SWCNH is a relatively innocuous nanomaterial when delivered to mice in vivo using aspiration as a delivery mechanism.

Authors:
 [1];  [1];  [1];  [1];  [2];  [2];  [1]
  1. ORNL
  2. University of Tennessee, Knoxville (UTK)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS); Mouse Genetics Research Facility
Sponsoring Org.:
USDOE Laboratory Directed Research and Development (LDRD) Program
OSTI Identifier:
931796
DOE Contract Number:  
DE-AC05-00OR22725
Resource Type:
Journal Article
Journal Name:
Nanotoxicology
Additional Journal Information:
Journal Volume: 1; Journal Issue: 2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CARBON; FIBROSIS; GENES; GRANULOMAS; IN VIVO; LAVAGE; LUNGS; LYMPHOKINES; MICE; NANOTUBES; TOXICITY

Citation Formats

Lynch, Rachel M, Voy, Brynn H, Glass-Mattie, Dana F, Mahurin, Shannon Mark, Saxton, Arnold, Donnel, Robert L., and Cheng, Mengdawn. Assessing the pulmonary toxicity of single-walled carbon nanohorns. United States: N. p., 2007. Web. doi:10.1080/17435390701598496.
Lynch, Rachel M, Voy, Brynn H, Glass-Mattie, Dana F, Mahurin, Shannon Mark, Saxton, Arnold, Donnel, Robert L., & Cheng, Mengdawn. Assessing the pulmonary toxicity of single-walled carbon nanohorns. United States. https://doi.org/10.1080/17435390701598496
Lynch, Rachel M, Voy, Brynn H, Glass-Mattie, Dana F, Mahurin, Shannon Mark, Saxton, Arnold, Donnel, Robert L., and Cheng, Mengdawn. 2007. "Assessing the pulmonary toxicity of single-walled carbon nanohorns". United States. https://doi.org/10.1080/17435390701598496.
@article{osti_931796,
title = {Assessing the pulmonary toxicity of single-walled carbon nanohorns},
author = {Lynch, Rachel M and Voy, Brynn H and Glass-Mattie, Dana F and Mahurin, Shannon Mark and Saxton, Arnold and Donnel, Robert L. and Cheng, Mengdawn},
abstractNote = {Previous studies have suggested that single-walled carbon nanotubes (SWCNTs) may pose a pulmonary hazard. We investigated the pulmonary toxicity of single-walled carbon nanohorns (SWCNHs), a relatively new carbon-based nanomaterial that is structurally similar to SWCNTs. Mice were exposed to 30 {micro}g of surfactant-suspended SWCNHs or an equal volume of vehicle control by pharyngeal aspiration and sacrificed 24 hours or 7 days post-exposure. Total and differential cell counts and cytokine analysis of bronchoalveolar lavage fluid demonstrated a mild inflammatory response which was mitigated by day 7 post-exposure. Whole lung microarray analysis demonstrated that SWCNH-exposure did not lead to robust changes in gene expression. Finally, histological analysis showed no evidence of granuloma formation or fibrosis following SWCNH aspiration. These combined results suggest that SWCNH is a relatively innocuous nanomaterial when delivered to mice in vivo using aspiration as a delivery mechanism.},
doi = {10.1080/17435390701598496},
url = {https://www.osti.gov/biblio/931796}, journal = {Nanotoxicology},
number = 2,
volume = 1,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}