Assessing the pulmonary toxicity of single-walled carbon nanohorns
Abstract
Previous studies have suggested that single-walled carbon nanotubes (SWCNTs) may pose a pulmonary hazard. We investigated the pulmonary toxicity of single-walled carbon nanohorns (SWCNHs), a relatively new carbon-based nanomaterial that is structurally similar to SWCNTs. Mice were exposed to 30 {micro}g of surfactant-suspended SWCNHs or an equal volume of vehicle control by pharyngeal aspiration and sacrificed 24 hours or 7 days post-exposure. Total and differential cell counts and cytokine analysis of bronchoalveolar lavage fluid demonstrated a mild inflammatory response which was mitigated by day 7 post-exposure. Whole lung microarray analysis demonstrated that SWCNH-exposure did not lead to robust changes in gene expression. Finally, histological analysis showed no evidence of granuloma formation or fibrosis following SWCNH aspiration. These combined results suggest that SWCNH is a relatively innocuous nanomaterial when delivered to mice in vivo using aspiration as a delivery mechanism.
- Authors:
-
- ORNL
- University of Tennessee, Knoxville (UTK)
- Publication Date:
- Research Org.:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS); Mouse Genetics Research Facility
- Sponsoring Org.:
- USDOE Laboratory Directed Research and Development (LDRD) Program
- OSTI Identifier:
- 931796
- DOE Contract Number:
- DE-AC05-00OR22725
- Resource Type:
- Journal Article
- Journal Name:
- Nanotoxicology
- Additional Journal Information:
- Journal Volume: 1; Journal Issue: 2
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; CARBON; FIBROSIS; GENES; GRANULOMAS; IN VIVO; LAVAGE; LUNGS; LYMPHOKINES; MICE; NANOTUBES; TOXICITY
Citation Formats
Lynch, Rachel M, Voy, Brynn H, Glass-Mattie, Dana F, Mahurin, Shannon Mark, Saxton, Arnold, Donnel, Robert L., and Cheng, Mengdawn. Assessing the pulmonary toxicity of single-walled carbon nanohorns. United States: N. p., 2007.
Web. doi:10.1080/17435390701598496.
Lynch, Rachel M, Voy, Brynn H, Glass-Mattie, Dana F, Mahurin, Shannon Mark, Saxton, Arnold, Donnel, Robert L., & Cheng, Mengdawn. Assessing the pulmonary toxicity of single-walled carbon nanohorns. United States. https://doi.org/10.1080/17435390701598496
Lynch, Rachel M, Voy, Brynn H, Glass-Mattie, Dana F, Mahurin, Shannon Mark, Saxton, Arnold, Donnel, Robert L., and Cheng, Mengdawn. 2007.
"Assessing the pulmonary toxicity of single-walled carbon nanohorns". United States. https://doi.org/10.1080/17435390701598496.
@article{osti_931796,
title = {Assessing the pulmonary toxicity of single-walled carbon nanohorns},
author = {Lynch, Rachel M and Voy, Brynn H and Glass-Mattie, Dana F and Mahurin, Shannon Mark and Saxton, Arnold and Donnel, Robert L. and Cheng, Mengdawn},
abstractNote = {Previous studies have suggested that single-walled carbon nanotubes (SWCNTs) may pose a pulmonary hazard. We investigated the pulmonary toxicity of single-walled carbon nanohorns (SWCNHs), a relatively new carbon-based nanomaterial that is structurally similar to SWCNTs. Mice were exposed to 30 {micro}g of surfactant-suspended SWCNHs or an equal volume of vehicle control by pharyngeal aspiration and sacrificed 24 hours or 7 days post-exposure. Total and differential cell counts and cytokine analysis of bronchoalveolar lavage fluid demonstrated a mild inflammatory response which was mitigated by day 7 post-exposure. Whole lung microarray analysis demonstrated that SWCNH-exposure did not lead to robust changes in gene expression. Finally, histological analysis showed no evidence of granuloma formation or fibrosis following SWCNH aspiration. These combined results suggest that SWCNH is a relatively innocuous nanomaterial when delivered to mice in vivo using aspiration as a delivery mechanism.},
doi = {10.1080/17435390701598496},
url = {https://www.osti.gov/biblio/931796},
journal = {Nanotoxicology},
number = 2,
volume = 1,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}