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Title: Evolution of a Focal Brain Lesin Produced by Interlaced Microplanar X-rays

Abstract

Stereotactic radiosurgery has led to advances in the treatment of central nervous system disease. It relies upon the principle of delivering relatively high dose irradiation to a precise target, while exposing surrounding tissues to extremely low doses. We describe a novel radiosurgical approach using interlaced microplanar X-rays which we have termed 'microradiosurgery.' The use of microbeams allows for 1000-times greater precision than current clinically employed techniques. As a demonstration of this new method, we produced a -3.8 mm{sup 3} lesion in the rat brain. The lesion was followed over a period of 216 days using 9.4 Tesla magnetic resonance imaging. Our results show a gradually developing lesion at the site of the interlaced beams. The lesion began as a high T2 signal only, but advanced to include a central area of low T1 and mixed T2 signal within 2 months. No lesion was observed in the other side of the brain which was exposed to non-interlaced microbeams only. Interlaced microbeams is an effective method to create focal brain microlesions. This technique may allow the future treatment of pathology not accessible by surgical or more traditional radiosurgical means.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL) National Synchrotron Light Source
Sponsoring Org.:
Doe - Office Of Science
OSTI Identifier:
929981
Report Number(s):
BNL-80588-2008-JA
TRN: US0806679
DOE Contract Number:  
DE-AC02-98CH10886
Resource Type:
Journal Article
Resource Relation:
Journal Name: Minimally Invasive Neurosurgery; Journal Volume: 50
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; BEAMS; BRAIN; CENTRAL NERVOUS SYSTEM; CURRENTS; DOSES; IRRADIATION; MAGNETIC RESONANCE; PATHOLOGY; RADIOTHERAPY; RATS; SIGNALS; SURGERY; X RADIATION; national synchrotron light source

Citation Formats

Anschell,D., Romanelli, P., Benveniste, H., Foerster, B., Kalef-Ezra, J., Zhong, Z., and Dilmanian, F. Evolution of a Focal Brain Lesin Produced by Interlaced Microplanar X-rays. United States: N. p., 2007. Web. doi:10.1055/s-2007-976514.
Anschell,D., Romanelli, P., Benveniste, H., Foerster, B., Kalef-Ezra, J., Zhong, Z., & Dilmanian, F. Evolution of a Focal Brain Lesin Produced by Interlaced Microplanar X-rays. United States. doi:10.1055/s-2007-976514.
Anschell,D., Romanelli, P., Benveniste, H., Foerster, B., Kalef-Ezra, J., Zhong, Z., and Dilmanian, F. Mon . "Evolution of a Focal Brain Lesin Produced by Interlaced Microplanar X-rays". United States. doi:10.1055/s-2007-976514.
@article{osti_929981,
title = {Evolution of a Focal Brain Lesin Produced by Interlaced Microplanar X-rays},
author = {Anschell,D. and Romanelli, P. and Benveniste, H. and Foerster, B. and Kalef-Ezra, J. and Zhong, Z. and Dilmanian, F.},
abstractNote = {Stereotactic radiosurgery has led to advances in the treatment of central nervous system disease. It relies upon the principle of delivering relatively high dose irradiation to a precise target, while exposing surrounding tissues to extremely low doses. We describe a novel radiosurgical approach using interlaced microplanar X-rays which we have termed 'microradiosurgery.' The use of microbeams allows for 1000-times greater precision than current clinically employed techniques. As a demonstration of this new method, we produced a -3.8 mm{sup 3} lesion in the rat brain. The lesion was followed over a period of 216 days using 9.4 Tesla magnetic resonance imaging. Our results show a gradually developing lesion at the site of the interlaced beams. The lesion began as a high T2 signal only, but advanced to include a central area of low T1 and mixed T2 signal within 2 months. No lesion was observed in the other side of the brain which was exposed to non-interlaced microbeams only. Interlaced microbeams is an effective method to create focal brain microlesions. This technique may allow the future treatment of pathology not accessible by surgical or more traditional radiosurgical means.},
doi = {10.1055/s-2007-976514},
journal = {Minimally Invasive Neurosurgery},
number = ,
volume = 50,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}