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Title: Diffraction-enhanced Imaging of the Rat Spine

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Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL) National Synchrotron Light Source
Sponsoring Org.:
Doe - Office Of Science
OSTI Identifier:
Report Number(s):
DOE Contract Number:
Resource Type:
Journal Article
Resource Relation:
Journal Name: Canadian Association of Radiologists Journal (CARJ); Journal Volume: 57
Country of Publication:
United States
national synchrotron light source

Citation Formats

Kelly,M., Beavis, R., Fourney, D., Schultke, E., Parham, C., Juurlink, B., Zhong, Z., and Chapman, L. Diffraction-enhanced Imaging of the Rat Spine. United States: N. p., 2006. Web.
Kelly,M., Beavis, R., Fourney, D., Schultke, E., Parham, C., Juurlink, B., Zhong, Z., & Chapman, L. Diffraction-enhanced Imaging of the Rat Spine. United States.
Kelly,M., Beavis, R., Fourney, D., Schultke, E., Parham, C., Juurlink, B., Zhong, Z., and Chapman, L. Sun . "Diffraction-enhanced Imaging of the Rat Spine". United States. doi:.
title = {Diffraction-enhanced Imaging of the Rat Spine},
author = {Kelly,M. and Beavis, R. and Fourney, D. and Schultke, E. and Parham, C. and Juurlink, B. and Zhong, Z. and Chapman, L.},
abstractNote = {},
doi = {},
journal = {Canadian Association of Radiologists Journal (CARJ)},
number = ,
volume = 57,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 2006},
month = {Sun Jan 01 00:00:00 EST 2006}
  • Images of rat bone of different age groups (8, 56 and 78 weeks), lumbar vertebra and calcium hydroxyapatite phantom are obtained utilizing the diffraction-enhanced imaging technique. Images obtained with DEI are of superior quality and this novel technique may be an excellent choice for better visualization of the microstructure and the embedded spongiosa. Our motivation is to develop the optimizing tomography with the use of the data obtained at multiple energies.
  • For detailed biomedical observations using the optimum phase-contrast x-ray imaging, quantitative comparisons of imaging performances of two major imaging methods--x-ray interferometric imaging (XII) and diffraction enhanced imaging (DEI)--were performed. Density sensitivity and spatial resolution of each imaging method were evaluated using phantom tomograms obtained by each method with the same x-ray dosage. For practical comparison of the methods, biological samples were also observed under the same conditions. The results show that XII has a higher sensitivity than that of DEI and is thus suitable for observation of soft biological tissues. On the other hand, DEI has a wider dynamic rangemore » of density and is thus suitable for observation of samples with large differences in density of different regions.« less
  • Purpose: Radiotherapy remains a major treatment method for malignant tumors. Magnetic resonance imaging (MRI) is the standard modality for assessing glioma treatment response in the clinic. Compared to MRI, ultrasound imaging is low-cost and portable and can be used during intraoperative procedures. The purpose of this study was to quantitatively compare contrast-enhanced ultrasound (CEUS) imaging and MRI of irradiated gliomas in rats and to determine which quantitative ultrasound imaging parameters can be used for the assessment of early response to radiation in glioma. Methods: Thirteen nude rats with U87 glioma were used. A small thinned skull window preparation was performedmore » to facilitate ultrasound imaging and mimic intraoperative procedures. Both CEUS and MRI with structural, functional, and molecular imaging parameters were performed at preradiation and at 1 day and 4 days postradiation. Statistical analysis was performed to determine the correlations between MRI and CEUS parameters and the changes between pre- and postradiation imaging. Results: Area under the curve (AUC) in CEUS showed significant difference between preradiation and 4 days postradiation, along with four MRI parameters, T{sub 2}, apparent diffusion coefficient, cerebral blood flow, and amide proton transfer-weighted (APTw) (all p < 0.05). The APTw signal was correlated with three CEUS parameters, rise time (r = − 0.527, p < 0.05), time to peak (r = − 0.501, p < 0.05), and perfusion index (r = 458, p < 0.05). Cerebral blood flow was correlated with rise time (r = − 0.589, p < 0.01) and time to peak (r = − 0.543, p < 0.05). Conclusions: MRI can be used for the assessment of radiotherapy treatment response and CEUS with AUC as a new technique and can also be one of the assessment methods for early response to radiation in glioma.« less
  • No abstract prepared.