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Title: Subcellular boron and fluorine distributions with SIMS ion microscopy in BNCT and cancer research

Abstract

The development of a secondary ion mass spectrometry (SIMS) based technique of Ion Microscopy in boron neutron capture therapy (BNCT) was the main goal of this project, so that one can study the subcellular location of boron-10 atoms and their partitioning between the normal and cancerous tissue. This information is fundamental for the screening of boronated drugs appropriate for neutron capture therapy of cancer. Our studies at Cornell concentrated mainly on studies of glioblastoma multiforme (GBM). The early years of the grant were dedicated to the development of cryogenic methods and correlative microscopic approaches so that a reliable subcellular analysis of boron-10 atoms can be made with SIMS. In later years SIMS was applied to animal models and human tissues of GBM for studying the efficacy of potential boronated agents in BNCT. Under this grant the SIMS program at Cornell attained a new level of excellence and collaborative SIMS studies were published with leading BNCT researchers in the U.S.

Authors:
Publication Date:
Research Org.:
Cornell University
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
928974
Report Number(s):
DOE/ER/61138-1
TRN: US1002548
DOE Contract Number:  
FG02-91ER61138
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; ANIMAL TISSUES; ANIMALS; ATOMS; BORON; BORON 10; CRYOGENICS; FLUORINE; GLIOMAS; ION MICROSCOPY; MASS SPECTROSCOPY; NEOPLASMS; NEUTRON CAPTURE THERAPY; Boron Neutron Capture Therapy (BNCT)

Citation Formats

Subhash Chandra. Subcellular boron and fluorine distributions with SIMS ion microscopy in BNCT and cancer research. United States: N. p., 2008. Web. doi:10.2172/928974.
Subhash Chandra. Subcellular boron and fluorine distributions with SIMS ion microscopy in BNCT and cancer research. United States. doi:10.2172/928974.
Subhash Chandra. Fri . "Subcellular boron and fluorine distributions with SIMS ion microscopy in BNCT and cancer research". United States. doi:10.2172/928974. https://www.osti.gov/servlets/purl/928974.
@article{osti_928974,
title = {Subcellular boron and fluorine distributions with SIMS ion microscopy in BNCT and cancer research},
author = {Subhash Chandra},
abstractNote = {The development of a secondary ion mass spectrometry (SIMS) based technique of Ion Microscopy in boron neutron capture therapy (BNCT) was the main goal of this project, so that one can study the subcellular location of boron-10 atoms and their partitioning between the normal and cancerous tissue. This information is fundamental for the screening of boronated drugs appropriate for neutron capture therapy of cancer. Our studies at Cornell concentrated mainly on studies of glioblastoma multiforme (GBM). The early years of the grant were dedicated to the development of cryogenic methods and correlative microscopic approaches so that a reliable subcellular analysis of boron-10 atoms can be made with SIMS. In later years SIMS was applied to animal models and human tissues of GBM for studying the efficacy of potential boronated agents in BNCT. Under this grant the SIMS program at Cornell attained a new level of excellence and collaborative SIMS studies were published with leading BNCT researchers in the U.S.},
doi = {10.2172/928974},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri May 30 00:00:00 EDT 2008},
month = {Fri May 30 00:00:00 EDT 2008}
}

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