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Title: 1,2-Hydroxypyridonates as Contrast Agents for Magnetic ResonanceImaging: TREN-1,2-HOPO

Abstract

1,2-Hydroxypyridinones (1,2-HOPO) form very stable lanthanide complexes that may be useful as contrast agents for Magnetic Resonance Imaging (MRI). X-ray diffraction of single crystals established that the solid state structures of the Eu(III) and the previously reported [Inorg. Chem. 2004, 43, 5452] Gd(III) complex are identical. The recently discovered sensitizing properties of 1,2-HOPO chelates for Eu(III) luminescence allow direct measurement of the number if water molecules in the metal complex. Fluorescence measurements of the Eu(III) complex corroborate that in solution two water molecules coordinate the lanthanide (q = 2) as proposed from the analysis of NMRD profiles. In addition, fluorescence measurements have verified the anion binding interactions of lanthanide TREN-1,2-HOPO complexes in solution, studied by relaxivity, revealing only very weak oxalate binding (K{sub A} = 82.7 {+-} 6.5 M{sup -1}). Solution thermodynamic studies of the metal complex and free ligand have been carried out using potentiometry, spectrophotometry and fluorescence spectroscopy. The metal ion selectivity of TREN-1,2-HOPO supports the feasibility of using 1,2-HOPO ligands for selective lanthanide binding [pGd = 19.3 (2); pZn = 15.2 (2), pCa = 8.8 (3)].

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
Sponsoring Org.:
USDOE Director, Office of Science; National Institutes ofHealth
OSTI Identifier:
928585
Report Number(s):
LBNL-62682
Journal ID: ISSN 0020-1669; INOCAJ; R&D Project: 403015; BnR: KC0302030; TRN: US200811%%413
DOE Contract Number:  
DE-AC02-05CH11231; NIHHL69832
Resource Type:
Journal Article
Resource Relation:
Journal Name: Inorganic Chemistry; Journal Volume: 46; Journal Issue: 22; Related Information: Journal Publication Date: 10/03/2007
Country of Publication:
United States
Language:
English
Subject:
37; ANIONS; CHELATES; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; LUMINESCENCE; MAGNETIC RESONANCE; MONOCRYSTALS; OXALATES; POTENTIOMETRY; RARE EARTHS; SPECTROPHOTOMETRY; THERMODYNAMICS; WATER; X-RAY DIFFRACTION

Citation Formats

Jocher, Christoph J., Moore, Evan G., Xu, Jide, Avedano, Stefano, Botta, Mauro, Aime, Silvio, and Raymond, Kenneth N. 1,2-Hydroxypyridonates as Contrast Agents for Magnetic ResonanceImaging: TREN-1,2-HOPO. United States: N. p., 2007. Web. doi:10.1021/ic700985j.
Jocher, Christoph J., Moore, Evan G., Xu, Jide, Avedano, Stefano, Botta, Mauro, Aime, Silvio, & Raymond, Kenneth N. 1,2-Hydroxypyridonates as Contrast Agents for Magnetic ResonanceImaging: TREN-1,2-HOPO. United States. doi:10.1021/ic700985j.
Jocher, Christoph J., Moore, Evan G., Xu, Jide, Avedano, Stefano, Botta, Mauro, Aime, Silvio, and Raymond, Kenneth N. Tue . "1,2-Hydroxypyridonates as Contrast Agents for Magnetic ResonanceImaging: TREN-1,2-HOPO". United States. doi:10.1021/ic700985j. https://www.osti.gov/servlets/purl/928585.
@article{osti_928585,
title = {1,2-Hydroxypyridonates as Contrast Agents for Magnetic ResonanceImaging: TREN-1,2-HOPO},
author = {Jocher, Christoph J. and Moore, Evan G. and Xu, Jide and Avedano, Stefano and Botta, Mauro and Aime, Silvio and Raymond, Kenneth N.},
abstractNote = {1,2-Hydroxypyridinones (1,2-HOPO) form very stable lanthanide complexes that may be useful as contrast agents for Magnetic Resonance Imaging (MRI). X-ray diffraction of single crystals established that the solid state structures of the Eu(III) and the previously reported [Inorg. Chem. 2004, 43, 5452] Gd(III) complex are identical. The recently discovered sensitizing properties of 1,2-HOPO chelates for Eu(III) luminescence allow direct measurement of the number if water molecules in the metal complex. Fluorescence measurements of the Eu(III) complex corroborate that in solution two water molecules coordinate the lanthanide (q = 2) as proposed from the analysis of NMRD profiles. In addition, fluorescence measurements have verified the anion binding interactions of lanthanide TREN-1,2-HOPO complexes in solution, studied by relaxivity, revealing only very weak oxalate binding (K{sub A} = 82.7 {+-} 6.5 M{sup -1}). Solution thermodynamic studies of the metal complex and free ligand have been carried out using potentiometry, spectrophotometry and fluorescence spectroscopy. The metal ion selectivity of TREN-1,2-HOPO supports the feasibility of using 1,2-HOPO ligands for selective lanthanide binding [pGd = 19.3 (2); pZn = 15.2 (2), pCa = 8.8 (3)].},
doi = {10.1021/ic700985j},
journal = {Inorganic Chemistry},
number = 22,
volume = 46,
place = {United States},
year = {Tue May 08 00:00:00 EDT 2007},
month = {Tue May 08 00:00:00 EDT 2007}
}