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Title: Comment on ``Experimental Free Energy Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality''

Abstract

Harris, Song and Kiang [1] (HSK) describe their results on reconstructing the free energy profiles for both the stretch of the titin polymer, and the unfolding of an individual I27 domain. The new finding reported in [1] is the measurement of the free energy barrier (or activation energy) to unfolding the I27 domain. Due to a misinterpretation of the mechanics involved, the free energy surface (and thus the energy barrier) to unfolding the I27 domain was not measured.

Authors:
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
928521
Report Number(s):
LLNL-JRNL-400499
Journal ID: ISSN 0031-9007; PRLTAO; TRN: US0803279
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Journal Article
Journal Name:
Physical Review Letters
Additional Journal Information:
Journal Volume: 100; Journal Issue: 1; Journal ID: ISSN 0031-9007
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; ACTIVATION ENERGY; FREE ENERGY; SPECTROSCOPY

Citation Formats

Friddle, R W. Comment on ``Experimental Free Energy Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality''. United States: N. p., 2008. Web. doi:10.1103/PhysRevLett.100.019801.
Friddle, R W. Comment on ``Experimental Free Energy Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality''. United States. https://doi.org/10.1103/PhysRevLett.100.019801
Friddle, R W. Mon . "Comment on ``Experimental Free Energy Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality''". United States. https://doi.org/10.1103/PhysRevLett.100.019801. https://www.osti.gov/servlets/purl/928521.
@article{osti_928521,
title = {Comment on ``Experimental Free Energy Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality''},
author = {Friddle, R W},
abstractNote = {Harris, Song and Kiang [1] (HSK) describe their results on reconstructing the free energy profiles for both the stretch of the titin polymer, and the unfolding of an individual I27 domain. The new finding reported in [1] is the measurement of the free energy barrier (or activation energy) to unfolding the I27 domain. Due to a misinterpretation of the mechanics involved, the free energy surface (and thus the energy barrier) to unfolding the I27 domain was not measured.},
doi = {10.1103/PhysRevLett.100.019801},
url = {https://www.osti.gov/biblio/928521}, journal = {Physical Review Letters},
issn = {0031-9007},
number = 1,
volume = 100,
place = {United States},
year = {2008},
month = {1}
}

Works referenced in this record:

Experimental Free Energy Surface Reconstruction from Single-Molecule Force Spectroscopy using Jarzynski’s Equality
journal, August 2007


Free Energy Surfaces from Single-Molecule Force Spectroscopy
journal, July 2005


Free energy reconstruction from nonequilibrium single-molecule pulling experiments
journal, March 2001